Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder

Atiqul Haq Mazumder; Jennifer Barnett; Erkki Tapio Isometsä; Nina Lindberg; Minna Torniainen-Holm; Markku Lähteenvuo; Kaisla Lahdensuo; Martta Kerkelä; Ari Ahola-Olli; Jarmo Hietala; Olli Kampman; Tuula Kieseppä; Tuomas Jukuri; Katja Häkkinen; Erik Cederlöf; Willehard Haaki; Risto Kajanne; Asko Wegelius; Teemu Männynsalo; Jussi Niemi-Pynttäri; Kimmo Suokas; Jouko Lönnqvist; Jari Tiihonen; Tiina Paunio; Seppo Juhani Vainio; Aarno Palotie; Solja Niemelä; Jaana Suvisaari; Juha Veijola

doi:10.3390/brainsci11111422

Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder

Atiqul Haq Mazumder, Jennifer Barnett, Erkki Tapio Isometsä, Nina Lindberg, Minna Torniainen-Holm, Markku Lähteenvuo, Kaisla Lahdensuo, Martta Kerkelä, Ari Ahola-Olli, Jarmo Hietala, Olli Kampman, Tuula Kieseppä, Tuomas Jukuri, Katja Häkkinen, Erik Cederlöf, Willehard Haaki, Risto Kajanne, Asko Wegelius, Teemu Männynsalo, Jussi Niemi-PynttäriKimmo Suokas, Jouko Lönnqvist, Jari Tiihonen, Tiina Paunio, Seppo Juhani Vainio, Aarno Palotie, Solja Niemelä, Jaana Suvisaari, Juha Veijola

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Abstract

The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

Original language	English
Article number	1422
Journal	Brain Sciences
Volume	11
Issue number	11
DOIs	https://doi.org/10.3390/brainsci11111422
Publication status	Published - 2021
Publication type	A1 Journal article-refereed

Keywords

Bipolar disorder
Cognition
Hazardous drinking
PGS
Reaction time
Schizoaffective disorder
Schizophrenia
Visual memory

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

General Neuroscience

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10.3390/brainsci11111422

brainsci-11-01422-v3Final published version, 788 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202111168439Licence: CC BY

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Mazumder, A. H., Barnett, J., Isometsä, E. T., Lindberg, N., Torniainen-Holm, M., Lähteenvuo, M., Lahdensuo, K., Kerkelä, M., Ahola-Olli, A., Hietala, J., Kampman, O., Kieseppä, T., Jukuri, T., Häkkinen, K., Cederlöf, E., Haaki, W., Kajanne, R., Wegelius, A., Männynsalo, T., ... Veijola, J. (2021). Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder. Brain Sciences, 11(11), Article 1422. https://doi.org/10.3390/brainsci11111422

@article{0469e2afd9f848ebb4dfdb63d7e96ef3,

title = "Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder",

abstract = "The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.",

keywords = "Bipolar disorder, Cognition, Hazardous drinking, PGS, Reaction time, Schizoaffective disorder, Schizophrenia, Visual memory",

author = "Mazumder, {Atiqul Haq} and Jennifer Barnett and Isomets{\"a}, {Erkki Tapio} and Nina Lindberg and Minna Torniainen-Holm and Markku L{\"a}hteenvuo and Kaisla Lahdensuo and Martta Kerkel{\"a} and Ari Ahola-Olli and Jarmo Hietala and Olli Kampman and Tuula Kiesepp{\"a} and Tuomas Jukuri and Katja H{\"a}kkinen and Erik Cederl{\"o}f and Willehard Haaki and Risto Kajanne and Asko Wegelius and Teemu M{\"a}nnynsalo and Jussi Niemi-Pyntt{\"a}ri and Kimmo Suokas and Jouko L{\"o}nnqvist and Jari Tiihonen and Tiina Paunio and Vainio, {Seppo Juhani} and Aarno Palotie and Solja Niemel{\"a} and Jaana Suvisaari and Juha Veijola",

note = "Funding Information: The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Sk?odowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-M?llisen Foundation (Iso-M?llisen S??ti?) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622). Funding Information: Funding: The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Sk{\l}odowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-M{\"a}llisen Foundation (Iso-M{\"a}llisen S{\"a}{\"a}ti{\"o}) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622). Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/brainsci11111422",

language = "English",

volume = "11",

number = "11",

}

Mazumder, AH, Barnett, J, Isometsä, ET, Lindberg, N, Torniainen-Holm, M, Lähteenvuo, M, Lahdensuo, K, Kerkelä, M, Ahola-Olli, A, Hietala, J, Kampman, O, Kieseppä, T, Jukuri, T, Häkkinen, K, Cederlöf, E, Haaki, W, Kajanne, R, Wegelius, A, Männynsalo, T, Niemi-Pynttäri, J, Suokas, K, Lönnqvist, J, Tiihonen, J, Paunio, T, Vainio, SJ, Palotie, A, Niemelä, S, Suvisaari, J & Veijola, J 2021, 'Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder', Brain Sciences, vol. 11, no. 11, 1422. https://doi.org/10.3390/brainsci11111422

TY - JOUR

T1 - Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder

AU - Mazumder, Atiqul Haq

AU - Barnett, Jennifer

AU - Isometsä, Erkki Tapio

AU - Lindberg, Nina

AU - Torniainen-Holm, Minna

AU - Lähteenvuo, Markku

AU - Lahdensuo, Kaisla

AU - Kerkelä, Martta

AU - Ahola-Olli, Ari

AU - Hietala, Jarmo

AU - Kampman, Olli

AU - Kieseppä, Tuula

AU - Jukuri, Tuomas

AU - Häkkinen, Katja

AU - Cederlöf, Erik

AU - Haaki, Willehard

AU - Kajanne, Risto

AU - Wegelius, Asko

AU - Männynsalo, Teemu

AU - Niemi-Pynttäri, Jussi

AU - Suokas, Kimmo

AU - Lönnqvist, Jouko

AU - Tiihonen, Jari

AU - Paunio, Tiina

AU - Vainio, Seppo Juhani

AU - Palotie, Aarno

AU - Niemelä, Solja

AU - Suvisaari, Jaana

AU - Veijola, Juha

N1 - Funding Information: The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Sk?odowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-M?llisen Foundation (Iso-M?llisen S??ti?) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622). Funding Information: Funding: The work was supported by a grant from the Stanley Center for Psychiatric Research, Broad Institute, Cambridge, MA, USA (grant agreement nos. 6045290-5500000710 and 6000009-5500000710). The principal author was supported by the H2020 Marie Skłodowska-Curie Actions co-funding of regional, national, and international programs (COFUND) (grant agreement no. 713606) for his doctoral program (MSC-COFUND, I4FUTURE). The principal author was also supported by the Iso-Mällisen Foundation (Iso-Mällisen Säätiö) through a medical grant of EUR 4000 for the year 2019 (grant no. 0400 584622). Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021

Y1 - 2021

N2 - The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

AB - The purpose of this study was to explore the association of cognition with hazardous drinking Polygenic Scores (PGS) in 2649 schizophrenia, 558 schizoaffective disorder, and 1125 bipolar disorder patients in Finland. Hazardous drinking PGS was computed using the LDPred program. Participants performed two computerized tasks from the Cambridge Automated Neuropsychological Test Battery (CANTAB) on a tablet computer: the 5-choice serial reaction time task, or Reaction Time (RT) test, and the Paired Associative Learning (PAL) test. The association between hazardous drinking PGS and cognition was measured using four cognition variables. Log-linear regression was used in Reaction Time (RT) assessment, and logistic regression was used in PAL assessment. All analyses were conducted separately for males and females. After adjustment of age, age of onset, education, household pattern, and depressive symptoms, hazardous drinking PGS was not associated with reaction time or visual memory in male or female patients with schizophrenia, schizoaffective, and bipolar disorder.

KW - Bipolar disorder

KW - Cognition

KW - Hazardous drinking

KW - PGS

KW - Reaction time

KW - Schizoaffective disorder

KW - Schizophrenia

KW - Visual memory

U2 - 10.3390/brainsci11111422

DO - 10.3390/brainsci11111422

M3 - Article

AN - SCOPUS:85118269425

SN - 2076-3425

VL - 11

JO - Brain Sciences

JF - Brain Sciences

IS - 11

M1 - 1422

ER -

Reaction time and visual memory in connection to hazardous drinking polygenic scores in schizophrenia, schizoaffective and bipolar disorder

Abstract

Keywords

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ASJC Scopus subject areas

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