Redox-coupled proton transfer in the respiratory complex I

V. Kaila, A. P. Gamiz-Hernandez, V. Sharma, J. Warnau, A Jussupow, M Johansson, G Belevich, M. Verkhovskaya, G. Hummer, M. Wikström

    Research output: Other contributionpeer-review

    Abstract

    Complex I functions as a redox-driven proton pump in the
    aerobic respiratory chains of bacteria and eukaryotes. Re-
    markably, the electron transfer domain of complex I is sepa-
    rated by
    ca
    . 200
    ̊
    A from the most distant proton pathways.
    To understand the molecular mechanism of this biomolecular
    machine, we perform here large-scale classical and quantum
    molecular simulations, and site-directed mutagenesis experi-
    ments, to study how the quinone reduction triggers the func-
    tion of the proton pump. We find that coupled electrostatic,
    conformational, and hydration changes are central for estab-
    lishing the long-range energy coupling in complex I.
    Original languageEnglish
    TypeConference abstract
    Media of outputPoster
    Volume44
    Publication statusPublished - 2015

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