TY - JOUR
T1 - Reducing Sedentary Time and Whole-Body Insulin Sensitivity in Metabolic Syndrome
T2 - A 6-Month Randomized Controlled Trial
AU - Sjöros, Tanja
AU - Laine, Saara
AU - Garthwaite, Taru
AU - Vähä-Ypyä, Henri
AU - Löyttyniemi, Eliisa
AU - Koivumäki, Mikko
AU - Houttu, Noora
AU - Laitinen, Kirsi
AU - Kalliokoski, Kari K.
AU - Sievänen, Harri
AU - Vasankari, Tommi
AU - Knuuti, Juhani
AU - Heinonen, Ilkka H.A.
N1 - Funding Information:
The study was financially supported by the Finnish Cultural Foundation, the Juho Vainio Foundation, Academy of Finland, the Hospital District of Southwest Finland, the Yrjö Jahnsson Foundation, the Turku University Foundation, Diabetestutkimussäätiö (the Finnish Diabetes Research Foundation), and TYKS-foundation.
Funding Information:
The authors thank the staff in the Turku PET Centre, University of Turku, and the laboratory personnel in the Turku University Hospital Laboratory for their proficient assistance in conducting the study. This study was conducted within the Centre of Excellence in Cardiovascular and Metabolic Research, supported by the Academy of Finland, the University of Turku, Turku University Hospital, and Åbo Akademi University.
Publisher Copyright:
© Lippincott Williams & Wilkins.
PY - 2023/3
Y1 - 2023/3
N2 - Purpose This study aimed to investigate whether a reduction in daily sedentary behavior (SB) improves insulin sensitivity in adults with metabolic syndrome in 6 months, without adding intentional exercise training. Methods Sixty-four sedentary inactive middle-age adults with overweight and metabolic syndrome (mean (SD) age, 58 (7) yr; mean (SD) body mass index, 31.6 (4.3) kg·m-2; 27 men) were randomized into intervention and control groups. The 6-month individualized behavioral intervention supported by an interactive accelerometer and a mobile application aimed at reducing daily SB by 1 h compared with baseline. Insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by air displacement plethysmography, and fasting blood samples were analyzed before and after the intervention. SB and physical activity were measured with hip-worn accelerometers throughout the intervention. Results SB decreased by 40 (95% confidence interval, 17-65) min·d-1, and moderate-to-vigorous physical activity increased by 20 (95% confidence interval, 11-28) min·d-1 on average in the intervention group with no significant changes in these outcomes in the control group. After 6 months, fasting plasma insulin decreased (1 mU·L-1) in the intervention group compared with the control group (time-group, P = 0.0081), but insulin sensitivity did not change in either group. The changes in body mass or adiposity did not differ between groups. Among all participants, the changes in SB and body mass correlated inversely with the change in insulin sensitivity (r = -0.31, -0.44; P = 0.025, 0.0005, respectively). Conclusions An intervention aimed at reducing daily SB resulted in slightly decreased fasting insulin, but had no effects on insulin sensitivity or body adiposity. However, as the change in insulin sensitivity associated with the changes in SB and body mass, multifaceted interventions targeting to weight loss are likely to be beneficial in improving whole-body insulin sensitivity.
AB - Purpose This study aimed to investigate whether a reduction in daily sedentary behavior (SB) improves insulin sensitivity in adults with metabolic syndrome in 6 months, without adding intentional exercise training. Methods Sixty-four sedentary inactive middle-age adults with overweight and metabolic syndrome (mean (SD) age, 58 (7) yr; mean (SD) body mass index, 31.6 (4.3) kg·m-2; 27 men) were randomized into intervention and control groups. The 6-month individualized behavioral intervention supported by an interactive accelerometer and a mobile application aimed at reducing daily SB by 1 h compared with baseline. Insulin sensitivity by hyperinsulinemic euglycemic clamp, body composition by air displacement plethysmography, and fasting blood samples were analyzed before and after the intervention. SB and physical activity were measured with hip-worn accelerometers throughout the intervention. Results SB decreased by 40 (95% confidence interval, 17-65) min·d-1, and moderate-to-vigorous physical activity increased by 20 (95% confidence interval, 11-28) min·d-1 on average in the intervention group with no significant changes in these outcomes in the control group. After 6 months, fasting plasma insulin decreased (1 mU·L-1) in the intervention group compared with the control group (time-group, P = 0.0081), but insulin sensitivity did not change in either group. The changes in body mass or adiposity did not differ between groups. Among all participants, the changes in SB and body mass correlated inversely with the change in insulin sensitivity (r = -0.31, -0.44; P = 0.025, 0.0005, respectively). Conclusions An intervention aimed at reducing daily SB resulted in slightly decreased fasting insulin, but had no effects on insulin sensitivity or body adiposity. However, as the change in insulin sensitivity associated with the changes in SB and body mass, multifaceted interventions targeting to weight loss are likely to be beneficial in improving whole-body insulin sensitivity.
KW - ACCELEROMETRY
KW - INSULIN RESISTANCE
KW - METABOLIC SYNDROME
KW - OVERWEIGHT
KW - PHYSICAL ACTIVITY
KW - SEDENTARY BEHAVIOR
U2 - 10.1249/MSS.0000000000003054
DO - 10.1249/MSS.0000000000003054
M3 - Article
C2 - 36251378
AN - SCOPUS:85148113565
SN - 0195-9131
VL - 55
SP - 342
EP - 353
JO - Medicine and Science in Sports and Exercise
JF - Medicine and Science in Sports and Exercise
IS - 3
ER -