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Reducing the Risk of Cognitive Decline and Dementia: WHO Recommendations

  • Neerja Chowdhary*
  • , Corrado Barbui
  • , Kaarin J. Anstey
  • , Miia Kivipelto
  • , Mariagnese Barbera
  • , Ruth Peters
  • , Lidan Zheng
  • , Jenni Kulmala
  • , Ruth Stephen
  • , Cleusa P. Ferri
  • , Yves Joanette
  • , Huali Wang
  • , Adelina Comas-Herrera
  • , Charles Alessi
  • , Kusumadewi Suharya
  • , Kibachio J. Mwangi
  • , Ronald C. Petersen
  • , Ayesha A. Motala
  • , Shanthi Mendis
  • , Dorairaj Prabhakaran
  • Ameenah Bibi Mia Sorefan, Amit Dias, Riadh Gouider, Suzana Shahar, Kimberly Ashby-Mitchell, Martin Prince, Tarun Dua
*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

191 Citations (Scopus)
201 Downloads (Pure)

Abstract

With population ageing worldwide, dementia poses one of the greatest global challenges for health and social care in the 21st century. In 2019, around 55 million people were affected by dementia, with the majority living in low- and middle-income countries. Dementia leads to increased costs for governments, communities, families and individuals. Dementia is overwhelming for the family and caregivers of the person with dementia, who are the cornerstone of care and support systems throughout the world. To assist countries in addressing the global burden of dementia, the World Health Organisation (WHO) developed the Global Action Plan on the Public Health Response to Dementia 2017–2025. It proposes actions to be taken by governments, civil society, and other global and regional partners across seven action areas, one of which is dementia risk reduction. This paper is based on WHO Guidelines on risk reduction of cognitive decline and dementia and presents recommendations on evidence-based, multisectoral interventions for reducing dementia risks, considerations for their implementation and policy actions. These global evidence-informed recommendations were developed by WHO, following a rigorous guideline development methodology and involved a panel of academicians and clinicians with multidisciplinary expertise and representing geographical diversity. The recommendations are considered under three broad headings: lifestyle and behaviour interventions, interventions for physical health conditions and specific interventions. By supporting health and social care professionals, particularly by improving their capacity to provide gender and culturally appropriate interventions to the general population, the risk of developing dementia can be potentially reduced, or its progression delayed.

Original languageEnglish
Article number765584
JournalFrontiers in Neurology
Volume12
DOIs
Publication statusPublished - 10 Jan 2022
Publication typeA1 Journal article-refereed

Funding

KA is funded by NHMRC Fellowship 1102694. RP and LZ are funded by the NHMRC Dementia Centre for Research Collaboration. LZ is also funded by NHMRC Grant 1100579. MK is funded by Academy of Finland [Grants Nos. 317465 and 335524], the European Union Joint Programme – Neurodegenerative Disease (JPND) project EURO-FINGERS [Academy of Finland Grant No. 334804], Stiftelsen Stockholms Sjukhem, Center for Innovative Medicine (CIMED) at Karolinska Institutet, Knut and Alice Wallenberg Foundation, the Swedish Research Council for Health, Working Life and Welfare, Region Stockholm grants (ALF, NSV), and Konung Gustaf V:s och Drottning Victorias Frimurarstiftelse. AB and MB are funded by the European Research Council (ERC) [Grant No. 804371]. AB and RS are funded by the Finnish Cultural Foundatio. AB is also funded by the Academy of Finland [Grants Nos. 287490 and 319318] and Alzheimerfonden. The authors thank members of the Guideline Steering Group and the Expert review Group for their contribution in the development of the WHO Guidelines on Risk reduction of cognitive decline and dementia. We are also grateful for the funds received from Public Health England, United Kingdom; Centre for Disease Control and Prevention, United States of America to support the guideline development.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • cognitive decline
  • dementia
  • dementia risk reduction guidelines
  • dementia risk reduction trials
  • WHO guidelines

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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