Abstract
Optical properties of biological tissues, such as refractive index, are fundamental properties, intrinsically linked to a tissue s composition and structure. This study aims to investigate the variation of refractive index (RI) of human articular cartilage along the tissue depth (via collagen fibril orientation and optical density) and integrity (based on Mankin and Osteoarthritis Research Society International (OARSI) scores). The results show the relationship between RI and PG content ( p=0.042), collagen orientation ( p=0.037), and OARSI score ( p=0.072). When taken into account, the outcome of this study suggests that the RI of healthy cartilage differs from that of pathological cartilage ( p=0.072). This could potentially provide knowledge on how progressive tissue degeneration, such as osteoarthritis, affects changes in cartilage RI, which can, in turn, be used as a potential optical biomarker of tissue pathology.
| Original language | English |
|---|---|
| Pages (from-to) | 2205-2214 |
| Number of pages | 10 |
| Journal | Journal of the Optical Society of America A: Optics and Image Science, and Vision |
| Volume | 40 |
| Issue number | 12 |
| DOIs | |
| Publication status | Published - 21 Nov 2023 |
| Publication type | A1 Journal article-refereed |
Funding
Acknowledgment. Dr. Afara acknowledges funding from the Academy of Finland and Erkko Foundation. We acknowledge the Academy of Finland’s Photonics Research and Innovation (PREIN) flagship for financial support.
| Funders | Funder number |
|---|---|
| Jane and Aatos Erkko Foundation | |
| Academy of Finland |
Publication forum classification
- Publication forum level 1
ASJC Scopus subject areas
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Computer Vision and Pattern Recognition
Access to Document
- Final-accepted version-1
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