Resistance Training Increases White Matter Density in Frail Elderly Women

Marco Bucci, Patricia Iozzo, Harri Merisaari, Ville Huovinen, Heta Lipponen, Katri Räikkönen, Riitta Parkkola, Minna Salonen, Samuel Sandboge, Johan Gunnar Eriksson, Lauri Nummenmaa, Pirjo Nuutila

Research output: Contribution to journalArticleScientificpeer-review

1 Downloads (Pure)


We aimed to investigate the effects of maternal obesity on brain structure and metabolism in frail women, and their reversibility in response to exercise. We recruited 37 frail elderly women (20 offspring of lean/normal-weight mothers (OLM) and 17 offspring of obese/overweight mothers (OOM)) and nine non-frail controls to undergo magnetic resonance and diffusion tensor imaging (DTI), positron emission tomography with Fluorine-18-fluorodeoxyglucose (PET), and cognitive function tests (CERAD). Frail women were studied before and after a 4-month resistance training, and controls were studied once. White matter (WM) density (voxel-based morphometry) was higher in OLM than in OOM subjects. Exercise increased WM density in both OLM and OOM in the cerebellum in superior parietal regions in OLM and in cuneal and precuneal regions in OOM. OLM gained more WM density than OOM in response to intervention. No significant results were found from the Freesurfer analysis, nor from PET or DTI images. Exercise has an impact on brain morphology and cognition in elderly frail women.

Original languageEnglish
Article number2684
JournalJournal of Clinical Medicine
Issue number7
Publication statusPublished - Apr 2023
Publication typeA1 Journal article-refereed


  • aged
  • cognitive dysfunction/diagnosis
  • diffusion tensor imaging
  • female
  • frailty
  • glucose clamp technique
  • magnetic resonance imaging
  • positron-emission tomography
  • resistance training
  • VBM

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • General Medicine


Dive into the research topics of 'Resistance Training Increases White Matter Density in Frail Elderly Women'. Together they form a unique fingerprint.

Cite this