Respiratory infections and type 1 diabetes: Potential roles in pathogenesis

Roy Wu; Mohsin Mumtaz; Anna J. Maxwell; Sonia R. Isaacs; Jutta E. Laiho; William D. Rawlinson; Heikki Hyöty; Maria E. Craig; Ki Wook Kim

doi:10.1002/rmv.2429

Respiratory infections and type 1 diabetes: Potential roles in pathogenesis

Roy Wu, Mohsin Mumtaz, Anna J. Maxwell, Sonia R. Isaacs, Jutta E. Laiho, William D. Rawlinson, Heikki Hyöty, Maria E. Craig, Ki Wook Kim

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Abstract

Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.

Original language	English
Article number	e2429
Journal	REVIEWS IN MEDICAL VIROLOGY
Volume	33
Issue number	2
Early online date	2023
DOIs	https://doi.org/10.1002/rmv.2429
Publication status	Published - Mar 2023
Publication type	A2 Review article in a scientific journal

Keywords

autoimmunity
respiratory infection
type 1 diabetes
virome
virus

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Virology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/rmv.2429Licence: CC BY

Reviews in Medical Virology - 2023 - Wu - Respiratory infections and type 1 diabetes Potential roles in pathogenesisFinal published version, 445 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202303293300Licence: CC BY

Cite this

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title = "Respiratory infections and type 1 diabetes: Potential roles in pathogenesis",

abstract = "Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.",

keywords = "autoimmunity, respiratory infection, type 1 diabetes, virome, virus",

author = "Roy Wu and Mohsin Mumtaz and Maxwell, {Anna J.} and Isaacs, {Sonia R.} and Laiho, {Jutta E.} and Rawlinson, {William D.} and Heikki Hy{\"o}ty and Craig, {Maria E.} and Kim, {Ki Wook}",

note = "Funding Information: Ki Wook Kim was supported by the Juvenile Diabetes Research Foundation (JDRF) International Postdoctoral Fellowship 3‐PDF‐2020‐940‐A‐N, the ENDIA Science Continuation Grant funded by the Leona M. and Harry B. Helmsley Charitable Trust (HCT), and the ENDIA Early‐Mid Career Science Accelerator Award (Grant # 2‐SRA‐2021‐1083‐M‐B) funded by HCT and JDRF Australian Type 1 Diabetes Clinical Research Network the recipient of Australian Government Department of Health funding through the Emerging Priorities and Consumer‐Driven Research Initiative, part of the Medical Research Future Fund. M.E. Craig is supported by a National Health and Medical Research Council Practitioner fellowship APP1136735. S. Isaacs is supported by Australian Government Research Training Program Scholarship and the Environmental Determinants of Islet Autoimmunity (ENDIA) PhD top‐up scholarship. Publisher Copyright: {\textcopyright} 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.",

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AU - Wu, Roy

AU - Mumtaz, Mohsin

AU - Maxwell, Anna J.

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AU - Laiho, Jutta E.

AU - Rawlinson, William D.

AU - Hyöty, Heikki

AU - Craig, Maria E.

AU - Kim, Ki Wook

N1 - Funding Information: Ki Wook Kim was supported by the Juvenile Diabetes Research Foundation (JDRF) International Postdoctoral Fellowship 3‐PDF‐2020‐940‐A‐N, the ENDIA Science Continuation Grant funded by the Leona M. and Harry B. Helmsley Charitable Trust (HCT), and the ENDIA Early‐Mid Career Science Accelerator Award (Grant # 2‐SRA‐2021‐1083‐M‐B) funded by HCT and JDRF Australian Type 1 Diabetes Clinical Research Network the recipient of Australian Government Department of Health funding through the Emerging Priorities and Consumer‐Driven Research Initiative, part of the Medical Research Future Fund. M.E. Craig is supported by a National Health and Medical Research Council Practitioner fellowship APP1136735. S. Isaacs is supported by Australian Government Research Training Program Scholarship and the Environmental Determinants of Islet Autoimmunity (ENDIA) PhD top‐up scholarship. Publisher Copyright: © 2023 The Authors. Reviews in Medical Virology published by John Wiley & Sons Ltd.

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N2 - Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.

AB - Among the environmental factors associated with type 1 diabetes (T1D), viral infections of the gut and pancreas has been investigated most intensely, identifying enterovirus infections as the prime candidate trigger of islet autoimmunity (IA) and T1D development. However, the association between respiratory tract infections (RTI) and IA/T1D is comparatively less known. While there are significant amounts of epidemiological evidence supporting the role of respiratory infections in T1D, there remains a paucity of data characterising infectious agents at the molecular level. This gap in the literature precludes the identification of the specific infectious agents driving the association between RTI and T1D. Furthermore, the effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections on the development of IA/T1D remains undeciphered. Here, we provide a comprehensive overview of the evidence to date, implicating RTIs (viral and non-viral) as potential risk factors for IA/T1D.

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KW - virome

KW - virus

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AN - SCOPUS:85148372067

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JO - REVIEWS IN MEDICAL VIROLOGY

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M1 - e2429

ER -

Respiratory infections and type 1 diabetes: Potential roles in pathogenesis

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

UN SDGs

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