RNA-protein interactions in vivo: Global gets specific

Minna-Liisa Änkö, Karla M. Neugebauer

Research output: Contribution to journalReview Articlepeer-review

62 Citations (Scopus)

Abstract

RNA-binding proteins (RBPs) impact every process in the cell; they act as splicing and polyadenylation factors, transport and localization factors, stabilizers and destabilizers, modifiers, and chaperones. RNA-binding capacity can be attributed to numerous protein domains that bind a limited repertoire of short RNA sequences. How is specificity achieved in cells? Here we focus on recent advances in determining the RNA-binding properties of proteins in vivo and compare these to in vitro determinations, highlighting insights into how endogenous RNA molecules are recognized and regulated. We also discuss the crucial contribution of structural determinations for understanding RNA-binding specificity and mechanisms.

Original languageEnglish
Pages (from-to)255-262
Number of pages8
JournalTRENDS IN BIOCHEMICAL SCIENCES
Volume37
Issue number7
DOIs
Publication statusPublished - Jul 2012
Externally publishedYes
Publication typeA2 Review article in a scientific journal

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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