Segmental arterial mediolysis leading to spontaneous rupture of splenic artery and fatal hemorrhage in pregnancy

Silvia Farkašová Iannaccone; Ivana Kholová; Alžbeta Ginelliová; Lucia Fröhlichová; Daniel Farkaš

doi:10.1016/j.carpath.2024.107650

Segmental arterial mediolysis leading to spontaneous rupture of splenic artery and fatal hemorrhage in pregnancy

Silvia Farkašová Iannaccone, Ivana Kholová, Alžbeta Ginelliová, Lucia Fröhlichová, Daniel Farkaš

Research output: Contribution to journal › Article › Scientific › peer-review

9 Downloads (Pure)

Abstract

We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission. The autopsy revealed ruptured splenic artery at the pancreatic tail and near the splenic hilum. Microscopically, different stages of segmental arterial mediolysis were observed in partially thinned and aneurysmatic artery.

Original language	English
Article number	107650
Journal	Cardiovascular Pathology
Volume	71
DOIs	https://doi.org/10.1016/j.carpath.2024.107650
Publication status	Published - 1 Jul 2024
Publication type	A1 Journal article-refereed

Keywords

Hemoperitoneum
Pregnancy
Segmental arterial mediolysis
Splenic artery
Splenic artery aneurysm
Spontaneous bleeding

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Pathology and Forensic Medicine
Cardiology and Cardiovascular Medicine

Access to Document

10.1016/j.carpath.2024.107650Licence: CC BY

1-s2.0-S1054880724000462-mainFinal published version, 3.08 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202405286369Licence: CC BY

Cite this

@article{7794b632d13d4ec68a778a0013274985,

title = "Segmental arterial mediolysis leading to spontaneous rupture of splenic artery and fatal hemorrhage in pregnancy",

abstract = "We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission. The autopsy revealed ruptured splenic artery at the pancreatic tail and near the splenic hilum. Microscopically, different stages of segmental arterial mediolysis were observed in partially thinned and aneurysmatic artery.",

keywords = "Hemoperitoneum, Pregnancy, Segmental arterial mediolysis, Splenic artery, Splenic artery aneurysm, Spontaneous bleeding",

author = "{Farka{\v s}ov{\'a} Iannaccone}, Silvia and Ivana Kholov{\'a} and Al{\v z}beta Ginelliov{\'a} and Lucia Fr{\"o}hlichov{\'a} and Daniel Farka{\v s}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = jul,

day = "1",

doi = "10.1016/j.carpath.2024.107650",

language = "English",

volume = "71",

journal = "Cardiovascular Pathology",

issn = "1054-8807",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Segmental arterial mediolysis leading to spontaneous rupture of splenic artery and fatal hemorrhage in pregnancy

AU - Farkašová Iannaccone, Silvia

AU - Kholová, Ivana

AU - Ginelliová, Alžbeta

AU - Fröhlichová, Lucia

AU - Farkaš, Daniel

PY - 2024/7/1

Y1 - 2024/7/1

N2 - We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission. The autopsy revealed ruptured splenic artery at the pancreatic tail and near the splenic hilum. Microscopically, different stages of segmental arterial mediolysis were observed in partially thinned and aneurysmatic artery.

AB - We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission. The autopsy revealed ruptured splenic artery at the pancreatic tail and near the splenic hilum. Microscopically, different stages of segmental arterial mediolysis were observed in partially thinned and aneurysmatic artery.

KW - Hemoperitoneum

KW - Pregnancy

KW - Segmental arterial mediolysis

KW - Splenic artery

KW - Splenic artery aneurysm

KW - Spontaneous bleeding

U2 - 10.1016/j.carpath.2024.107650

DO - 10.1016/j.carpath.2024.107650

M3 - Article

C2 - 38677635

AN - SCOPUS:85193250869

SN - 1054-8807

VL - 71

JO - Cardiovascular Pathology

JF - Cardiovascular Pathology

M1 - 107650

ER -

Segmental arterial mediolysis leading to spontaneous rupture of splenic artery and fatal hemorrhage in pregnancy

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

Access to Document

Fingerprint

Cite this