Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Saliha Selin Özuygur Ermis; Magnus P. Borres; Rani Basna; Linda Ekerljung; Carina Malmhäll; Emma Goksör; Göran Wennergren; Madeleine Rådinger; Jan Lötvall; Bo Lundbäck; Hannu Kankaaranta; Bright I. Nwaru

doi:10.1111/cea.14216

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Saliha Selin Özuygur Ermis^*
, Magnus P. Borres
, Rani Basna
, Linda Ekerljung
, Carina Malmhäll
, Emma Goksör
, Göran Wennergren
, Madeleine Rådinger
, Jan Lötvall
, Bo Lundbäck
, Hannu Kankaaranta
, Bright I. Nwaru

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

16 Citations (Scopus)

24 Downloads (Pure)

Abstract

Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.

Original language	English
Pages (from-to)	88-104
Journal	Clinical and Experimental Allergy
Volume	53
Issue number	1
Early online date	2022
DOIs	https://doi.org/10.1111/cea.14216
Publication status	Published - 2023
Publication type	A1 Journal article-refereed

Funding

The VBG Group Herman Krefting Foundation for Asthma and Allergy Research, Sweden, is gratefully acknowledged for funding the study. Additional funding was received from Sasakawa Scandinavia Foundation, Japan, the Swedish Research Council, the Swedish Heart‐Lung Foundation, the Swedish Asthma and Allergy Foundation, Thermofisher Scientific and ALF agreement (Västra Götaland) (Grants from the Swedish state under the agreement between the Swedish Government and the county councils). The authors are grateful to the research assistants/SRNs Helén Törnqvist, Maryanne Raneklint and Lotte Edvardsson, University of Gothenburg, for performing the major part of the data collection, to Eva‐Marie Romell for administrative support and to Henry Åkerström for performing the IgE analyses. We appreciate the support from professor Hironori Sagara and Doctor Akihiko Tanaka of ShowaUniversity, Tokyo, Japan. BN acknowledges the support of Knut and Alice Wallenberg Foundation and the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg.

Keywords

Can f 1
Can f 5
component resolved diagnostics
dog allergy
dog dander sensitization
dog molecular allergen components
furry animal allergy

Publication forum classification

Publication forum level 2

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1111/cea.14216Licence: CC BY

Clin Experimental Allergy - 2022 - zuygur Ermis - Sensitization to molecular dog allergens in an adult population ResultsFinal published version, 5.39 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202209207168Licence: CC BY

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Özuygur Ermis, S. S., Borres, M. P., Basna, R., Ekerljung, L., Malmhäll, C., Goksör, E., Wennergren, G., Rådinger, M., Lötvall, J., Lundbäck, B., Kankaaranta, H., & Nwaru, B. I. (2023). Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study. Clinical and Experimental Allergy, 53(1), 88-104. https://doi.org/10.1111/cea.14216

@article{1a69efa0752e44fc83486499a53cc39f,

title = "Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study",

abstract = "Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP{\texttrademark}. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70\%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43\%) was the most common, followed by Can f 5 (33\%) among molecular allergens, while sensitization to lipocalins (56\%) was the most common among component families. Polysensitization was found in 22\% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.",

keywords = "Can f 1, Can f 5, component resolved diagnostics, dog allergy, dog dander sensitization, dog molecular allergen components, furry animal allergy",

author = "\{{\"O}zuygur Ermis\}, \{Saliha Selin\} and Borres, \{Magnus P.\} and Rani Basna and Linda Ekerljung and Carina Malmh{\"a}ll and Emma Goks{\"o}r and G{\"o}ran Wennergren and Madeleine R{\aa}dinger and Jan L{\"o}tvall and Bo Lundb{\"a}ck and Hannu Kankaaranta and Nwaru, \{Bright I.\}",

note = "Funding Information: The VBG Group Herman Krefting Foundation for Asthma and Allergy Research, Sweden, is gratefully acknowledged for funding the study. Additional funding was received from Sasakawa Scandinavia Foundation, Japan, the Swedish Research Council, the Swedish Heart‐Lung Foundation, the Swedish Asthma and Allergy Foundation, Thermofisher Scientific and ALF agreement (V{\"a}stra G{\"o}taland) (Grants from the Swedish state under the agreement between the Swedish Government and the county councils). Funding Information: The authors are grateful to the research assistants/SRNs Hel{\'e}n T{\"o}rnqvist, Maryanne Raneklint and Lotte Edvardsson, University of Gothenburg, for performing the major part of the data collection, to Eva‐Marie Romell for administrative support and to Henry {\AA}kerstr{\"o}m for performing the IgE analyses. We appreciate the support from professor Hironori Sagara and Doctor Akihiko Tanaka of ShowaUniversity, Tokyo, Japan. BN acknowledges the support of Knut and Alice Wallenberg Foundation and the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg. Publisher Copyright: {\textcopyright} 2022 The Authors. Clinical \& Experimental Allergy published by John Wiley \& Sons Ltd.",

year = "2023",

doi = "10.1111/cea.14216",

language = "English",

volume = "53",

pages = "88--104",

journal = "Clinical and Experimental Allergy",

issn = "0954-7894",

publisher = "Wiley-Blackwell",

number = "1",

}

Özuygur Ermis, SS, Borres, MP, Basna, R, Ekerljung, L, Malmhäll, C, Goksör, E, Wennergren, G, Rådinger, M, Lötvall, J, Lundbäck, B, Kankaaranta, H & Nwaru, BI 2023, 'Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study', Clinical and Experimental Allergy, vol. 53, no. 1, pp. 88-104. https://doi.org/10.1111/cea.14216

TY - JOUR

T1 - Sensitization to molecular dog allergens in an adult population

T2 - Results from the West Sweden Asthma Study

AU - Özuygur Ermis, Saliha Selin

AU - Borres, Magnus P.

AU - Basna, Rani

AU - Ekerljung, Linda

AU - Malmhäll, Carina

AU - Goksör, Emma

AU - Wennergren, Göran

AU - Rådinger, Madeleine

AU - Lötvall, Jan

AU - Lundbäck, Bo

AU - Kankaaranta, Hannu

AU - Nwaru, Bright I.

N1 - Funding Information: The VBG Group Herman Krefting Foundation for Asthma and Allergy Research, Sweden, is gratefully acknowledged for funding the study. Additional funding was received from Sasakawa Scandinavia Foundation, Japan, the Swedish Research Council, the Swedish Heart‐Lung Foundation, the Swedish Asthma and Allergy Foundation, Thermofisher Scientific and ALF agreement (Västra Götaland) (Grants from the Swedish state under the agreement between the Swedish Government and the county councils). Funding Information: The authors are grateful to the research assistants/SRNs Helén Törnqvist, Maryanne Raneklint and Lotte Edvardsson, University of Gothenburg, for performing the major part of the data collection, to Eva‐Marie Romell for administrative support and to Henry Åkerström for performing the IgE analyses. We appreciate the support from professor Hironori Sagara and Doctor Akihiko Tanaka of ShowaUniversity, Tokyo, Japan. BN acknowledges the support of Knut and Alice Wallenberg Foundation and the Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg. Publisher Copyright: © 2022 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.

PY - 2023

Y1 - 2023

N2 - Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.

AB - Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.

KW - Can f 1

KW - Can f 5

KW - component resolved diagnostics

KW - dog allergy

KW - dog dander sensitization

KW - dog molecular allergen components

KW - furry animal allergy

U2 - 10.1111/cea.14216

DO - 10.1111/cea.14216

M3 - Article

C2 - 35984703

AN - SCOPUS:85137192797

SN - 0954-7894

VL - 53

SP - 88

EP - 104

JO - Clinical and Experimental Allergy

JF - Clinical and Experimental Allergy

IS - 1

ER -

Sensitization to molecular dog allergens in an adult population: Results from the West Sweden Asthma Study

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

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