TY - JOUR
T1 - Serum ceramides in early pregnancy as predictors of gestational diabetes
AU - Mustaniemi, Sanna
AU - Keikkala, Elina
AU - Kajantie, Eero
AU - Nurhonen, Markku
AU - Jylhä, Antti
AU - Morin-Papunen, Laure
AU - Öhman, Hanna
AU - Männistö, Tuija
AU - Laivuori, Hannele
AU - Eriksson, Johan G.
AU - Laaksonen, Reijo
AU - Vääräsmäki, Marja
AU - Kaaja, Risto
AU - Gissler, Mika
AU - Pouta, Anneli
N1 - Funding Information:
We thank the research coordinator M. Alaraappana (Northern Finland Laboratory Centre Nordlab, Oulu, Finland), the laboratory assistants S. Kuusiniemi (Biobank Borealis of Northern Finland, Oulu University Hospital, Oulu, Finland) and M. Halmetoja (Zora Biosciences Oy, Espoo, Finland), the members of the FinnGeDi Study Group emeritus professor R. Kaaja (University of Turku, Turku, Finland), professor M. Gissler (Finnish Institute for Health and Welfare, Helsinki, Finland) and adjunt professor A. Pouta (Finnish Institute for Health and Welfare, Helsinki, Finland), and the participants and the research staff of the FinnGeDi study.
Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023/12
Y1 - 2023/12
N2 - Ceramides contribute to the development of type 2 diabetes but it is uncertain whether they predict gestational diabetes (GDM). In this multicentre case–control study including 1040 women with GDM and 958 non-diabetic controls, early pregnancy (mean 10.7 gestational weeks) concentrations of four ceramides—Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)—were determined by a validated mass-spectrometric method from biobanked serum samples. Traditional lipids including total cholesterol, LDL, HDL and triglycerides were measured. Logistic and linear regression and the LASSO logistic regression were used to analyse lipids and clinical risk factors in the prediction of GDM. The concentrations of four targeted ceramides and total cholesterol, LDL and triglycerides were higher and HDL was lower among women with subsequent GDM than among controls. After adjustments, Cer(d18:1/24:0), triglycerides and LDL were independent predictors of GDM, women in their highest quartile had 1.44-fold (95% CI 1.07–1.95), 2.17-fold (95% CI 1.57–3.00) and 1.63-fold (95% CI 1.19–2.24) odds for GDM when compared to their lowest quartiles, respectively. In the LASSO regression modelling ceramides did not appear to markedly improve the predictive performance for GDM alongside with clinical risk factors and triglycerides. However, their adverse alterations highlight the extent of metabolic disturbances involved in GDM.
AB - Ceramides contribute to the development of type 2 diabetes but it is uncertain whether they predict gestational diabetes (GDM). In this multicentre case–control study including 1040 women with GDM and 958 non-diabetic controls, early pregnancy (mean 10.7 gestational weeks) concentrations of four ceramides—Cer(d18:1/16:0), Cer(d18:1/18:0), Cer(d18:1/24:0) and Cer(d18:1/24:1)—were determined by a validated mass-spectrometric method from biobanked serum samples. Traditional lipids including total cholesterol, LDL, HDL and triglycerides were measured. Logistic and linear regression and the LASSO logistic regression were used to analyse lipids and clinical risk factors in the prediction of GDM. The concentrations of four targeted ceramides and total cholesterol, LDL and triglycerides were higher and HDL was lower among women with subsequent GDM than among controls. After adjustments, Cer(d18:1/24:0), triglycerides and LDL were independent predictors of GDM, women in their highest quartile had 1.44-fold (95% CI 1.07–1.95), 2.17-fold (95% CI 1.57–3.00) and 1.63-fold (95% CI 1.19–2.24) odds for GDM when compared to their lowest quartiles, respectively. In the LASSO regression modelling ceramides did not appear to markedly improve the predictive performance for GDM alongside with clinical risk factors and triglycerides. However, their adverse alterations highlight the extent of metabolic disturbances involved in GDM.
U2 - 10.1038/s41598-023-40224-3
DO - 10.1038/s41598-023-40224-3
M3 - Article
C2 - 37582815
AN - SCOPUS:85168069069
SN - 2045-2322
VL - 13
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 13274
ER -
