Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

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    Abstract

    A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.
    Original languageEnglish
    Title of host publicationComputing in Cardiology 2017
    EditorsC Pickett, C Corsi, P Laguna, R MacLeod
    Pages1-4
    Number of pages4
    Volume44
    DOIs
    Publication statusPublished - 2017
    Publication typeA4 Article in conference proceedings
    EventCOMPUTING IN CARDIOLOGY CONFERENCE -
    Duration: 1 Jan 2017 → …

    Publication series

    NameComputing in Cardiology
    ISSN (Print)2325-8861

    Conference

    ConferenceCOMPUTING IN CARDIOLOGY CONFERENCE
    Period1/01/17 → …

    Publication forum classification

    • Publication forum level 1

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