Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

Jiyeong Kim; Jukka Kuusela; Katriina Aalto-Setälä; Esa Räsänen

doi:10.22489/cinc.2017.207-155

Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

Jiyeong Kim
, Jukka Kuusela
, Katriina Aalto-Setälä
, Esa Räsänen

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

2 Citations (Scopus)

16 Downloads (Pure)

Abstract

A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

Original language	English
Title of host publication	Computing in Cardiology 2017
Editors	C Pickett, C Corsi, P Laguna, R MacLeod
Pages	1-4
Number of pages	4
Volume	44
DOIs	https://doi.org/10.22489/cinc.2017.207-155
Publication status	Published - 2017
Publication type	A4 Article in conference proceedings
Event	COMPUTING IN CARDIOLOGY CONFERENCE - Duration: 1 Jan 2017 → …

Publication series

Name	Computing in Cardiology
ISSN (Print)	2325-8861

Conference

Conference	COMPUTING IN CARDIOLOGY CONFERENCE
Period	1/01/17 → …

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SDG 3 Good Health and Well-being

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10.22489/cinc.2017.207-155

Short- and Long-Range Correlations in Beat RateFinal published version, 292 KBLicence: Other

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@inproceedings{1c3bfbbc2ca24e4789e50dd622ec7de2,

title = "Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes",

abstract = "A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.",

author = "Jiyeong Kim and Jukka Kuusela and Katriina Aalto-Set{\"a}l{\"a} and Esa R{\"a}s{\"a}nen",

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year = "2017",

doi = "10.22489/cinc.2017.207-155",

language = "English",

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Kim, J, Kuusela, J, Aalto-Setälä, K & Räsänen, E 2017, Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes. in C Pickett, C Corsi, P Laguna & R MacLeod (eds), Computing in Cardiology 2017. vol. 44, Computing in Cardiology, pp. 1-4, COMPUTING IN CARDIOLOGY CONFERENCE, 1/01/17. https://doi.org/10.22489/cinc.2017.207-155

Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes. / Kim, Jiyeong; Kuusela, Jukka; Aalto-Setälä, Katriina et al.
Computing in Cardiology 2017. ed. / C Pickett; C Corsi; P Laguna; R MacLeod. Vol. 44 2017. p. 1-4 (Computing in Cardiology).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review

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T1 - Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

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AU - Räsänen, Esa

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N2 - A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

AB - A healthy heart exhibits fractal, i.e., long-range correlated fluctuations in heart rate variability (HRV). It is recently shown that fractal dynamics is also an intrinsic feature of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). In this study, we investigate short- and long-range correlations in beat rate variability (BRV) of hiPSC-CMs, obtained from a healthy subject and symptomatic and asymptomatic long QT syndrome patients. It is shown that it is important to distinguish correlation properties in short and long time scales, as the scaling exponents are significantly different and also behave differently in the acute exposure to pharmacological compounds that modulate β1-adrenoreceptors and cardiac ion channel generating delayed, outwardly rectifying K+ current (IKs). While long-range scaling is sensitive to the drug exposure, short-range scaling is barely affected.

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Short- and Long-Range Correlations in Beat Rate Variability of Human Pluripotent-Stem-Cell-Derived Cardiomyocytes

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