Small subgroup of aggressive, highly proliferative prostatic carcinomas defined by p53 accumulation

Tapio Visakorpi, Olli P. Kallioniemi, Asko Heikkinen, Timo Koivula, Jorma Isola

    Research output: Contribution to journalArticleScientificpeer-review

    283 Citations (Scopus)

    Abstract

    Background: Mutations in the p53 gene resulting in the accumulation of altered p53 proteins with prolonged half-life have been found in a large variety of human malignancies. Purpose: We studied the significance of p53 protein accumulation in prostatic carcinoma. Methods: The material consisted of 137 paraffin-embedded, primary prostatic carcinomas. Accumulation of p53 protein was studied by immunohistochemical staining using a polyclonal p53-specific CM-1 antibody. Proliferation activity was determined by DNA flow cytometry and by immunohistochemical detection of proliferative cell nuclear antigen (PCNA) using a monoclonal PC10 antibody.Results: Eight (6%) of the tumors showed intense p53 staining in more than 20% of the tumor cells, 15 (11%) had only lower level immunoreactivity, and 114 (83%) showed no staining. High-level p53 accumulation was associated with high histologic grade (P>.001), DNA aneuploidy (P>.05), and high cell profieration rate as defined by flow cytometric S-phase analysis (p>.01) or PCNA expression (P>.01). High-level p53 accumulation predicted short, progression-free interval (P>.01) and poor survival (P>.01), with about a 12-fold relative risk of deatha as compared with p53-negative cases. Low-level p53 accumulation had no prognostic significance. Conclusions:Accumulation of p53 confers proliferative advantage for prostatic carcinoma cells and defines a small subgroup of highly malignant carcinomas. (J Natl Cancer Inst 84:883-887, 1992]

    Original languageEnglish
    Pages (from-to)883-887
    Number of pages5
    JournalJOURNAL OF THE NATIONAL CANCER INSTITUTE
    Volume84
    Issue number11
    DOIs
    Publication statusPublished - 3 Jun 1992
    Publication typeA1 Journal article-refereed

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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