Stochastic modeling of inositol-1,4,5-trisphosphate receptors in Purkinje cell spine

K. Hituri, P. Achard, S. Wils, M-L. Linne, E. De Schutter

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    Transient rises in cytosolic calcium concentration play a crucial role in initiating long-term depression (LTD) of synaptic activity. Calcium release from endoplasmic reticulum is particularly important in LTD. In Purkinje cells, the release is mediated by inositol-1,4,5-trisphosphate (IP₃) receptors (IP₃Rs) that are highly expressed in dendritic spines. The small volume of spine and the small number of molecules involved increase stochasticity in biochemical processes. We studied the effects of stochasticity by comparing stochastic and deterministic simulations for two different IP₃R models. We found a significant difference between the responses when using small initial concentration of calcium or IP₃. Deterministic simulations of IP₃R activation do not produce realistic results under all conditions.
    Translated title of the contributionStochastic modeling of inositol-1,4,5-trisphosphate receptors in Purkinje cell spine
    Original languageEnglish
    Title of host publicationProceedings of the Fifth International Workshop on Computational Systems Biology, WCSB 2008, Leipzig, Germany, 11-13 June 2008
    EditorsM. Ahdesmäki
    Publication statusPublished - 2008
    Publication typeA4 Article in conference proceedings

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