Structure and in vitro dissolution of Mg and Sr containing borosilicate bioactive glasses for bone tissue engineering

J. M. Tainio, D. A. Avila Salazar, A. Nommeots-Nomm, C. Roiland, B. Bureau, D. R. Neuville, D. S. Brauer, J. Massera

Research output: Contribution to journalArticleScientificpeer-review

2 Citations (Scopus)


Borosilicate bioactive glasses are promising for bone tissue engineering. The objective was to assess the impact of magnesium and/or strontium, when substituted for calcium on the glasses' thermal and dissolution properties. Both Mg and Sr substitution appeared to enhance the hot forming domain, i.e. the ability to hot process (sinter, draw fibres) without adverse crystallization. Structural analysis indicated that substitution of MgO and/or SrO for CaO results in changes in the BO3/BO4 ratio as well as in the ratio between bridging and non-bridging oxygen atoms in the silicate structure. Additionally, a de-shielding effect was noticed when Ca, Mg and Sr are present together in the glass network, possibly owing to PO4 3− charge-balanced preferentially by Na+. The Mg and/or Sr substitution resulted in a lower ion release in simulated body fluid and delayed formation of hydroxyapatite. However, once this layer formed it consisted of a Mg/Sr-substituted apatite. This work highlights the effect of combined ionic substitutions on bioactive glass structure and properties.

Original languageEnglish
Article number119893
Number of pages10
JournalJournal of Non-Crystalline Solids
Publication statusPublished - 1 Apr 2020
Publication typeA1 Journal article-refereed


  • Bioactive glasses
  • Borosilicate glasses
  • In vitro dissolution
  • Structural properties
  • Tissue engineering

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Condensed Matter Physics
  • Materials Chemistry


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