TY - JOUR
T1 - SUCCOR 10 years
T2 - a decade's perspective on radical hysterectomy outcomes in cervical cancer
AU - SUCCOR 10-Year Study Group
AU - Manzour, Nabil
AU - Chiva, Luis
AU - Zanagnolo, Vanna
AU - Căpîlna, Mihai Emil
AU - Bizzarri, Nicolò
AU - Mom, Constantijne H.
AU - Klasa, Łukasz
AU - Arencibia, Octavio
AU - Malzoni, Mario
AU - Narducci, Fabrice
AU - Raspagliesi, Francesco
AU - Poka, Robert
AU - Golub, Dmytro
AU - Tavares, Mariana
AU - Tsolakidis, Dimitrios
AU - Shamistan, Aliyev
AU - Perrone, Anna Myriam
AU - Pete, Imre
AU - Aluloski, Igor
AU - Bernardino, Margarida
AU - Vujić, Goran
AU - Jedryka, Marcin
AU - Mäenpää, Minna
AU - Ponce, Jordi
AU - Povolotskaya, Natalia
AU - Roldan Rivas, Fernando
AU - Feron, Jean Guillaume
AU - Van Gorp, Toon
AU - Alonso-Espías, María
AU - Fruscio, Robert
AU - Vorgias, George
AU - Díez García, Javier
AU - Herrero, Sofía
AU - Kavallaris, Andreas
AU - Luyckx, Mathieu
AU - Yezhova, Iryna
AU - Mitrovic, Milena
AU - Ferrero, Annamaria
AU - Saaron, Reeli
AU - Sukhin, Vladyslav
N1 - Publisher Copyright:
© 2025 European Society of Gynaecological Oncology and the International Gynecologic Cancer Society
PY - 2025/5
Y1 - 2025/5
N2 - Objective: Interest in long-term outcomes of radical hysterectomy for cervical cancer has increased, especially after the LACC trial findings, which showed worse outcomes for minimally invasive surgery. However, limited information is available on 10-year oncological outcomes, particularly, recurrence and survival. The primary objective of this study was to analyze the 10-year oncological outcomes of patients with International Federation of Gynecology and Obstetrics 2009 stage IB1 cervical cancer treated with radical hysterectomy performed via minimally invasive or open approaches. Methods: This retrospective, multi-center, observational study updates the data from the SUCCOR cohort. Patients diagnosed between January 2013 and December 2014 with tumors ≤4 cm without extra-cervical metastasis and treated with radical hysterectomy as the primary treatment were included, and a 10-year follow-up after surgery was successfully conducted. Results: A total of 556 patients were analyzed. The median age was 46 years (range; 18-82). The most common final International Federation of Gynecology and Obstetrics 2009 stage was IB1, 474 patients (85%), and the most common histology was squamous carcinoma, 376 patients (67.6%). The 5-year disease-free survival was 93%, and the 10-year disease-free survival was 90%. The overall survival was 97% at 5 years and 89% at 10 years. During follow-up, 9% (n = 49) of patients experienced recurrences, 78% (n = 38) within the first 5 years. Comparing surgical approaches, 10-year disease-free survival was 92% for minimally invasive surgery and 88% for open surgery (p = .12). Similarly, 10-year overall survival was 92% for minimally invasive surgery and 88% for open surgery (p = .12). Post-recurrence disease-specific survival was 47% at 60 months and 39% at 96 months. The 2-year survival after recurrence was 80% for late recurrences (>5 years) versus 69% for early recurrences. Conclusions: The overall survival after radical hysterectomy at 5-years was 97% in patients with early-stage cervical cancer. The recurrence rate at 10 years was 9%. No differences in 10-year survival were observed between the surgical approaches.
AB - Objective: Interest in long-term outcomes of radical hysterectomy for cervical cancer has increased, especially after the LACC trial findings, which showed worse outcomes for minimally invasive surgery. However, limited information is available on 10-year oncological outcomes, particularly, recurrence and survival. The primary objective of this study was to analyze the 10-year oncological outcomes of patients with International Federation of Gynecology and Obstetrics 2009 stage IB1 cervical cancer treated with radical hysterectomy performed via minimally invasive or open approaches. Methods: This retrospective, multi-center, observational study updates the data from the SUCCOR cohort. Patients diagnosed between January 2013 and December 2014 with tumors ≤4 cm without extra-cervical metastasis and treated with radical hysterectomy as the primary treatment were included, and a 10-year follow-up after surgery was successfully conducted. Results: A total of 556 patients were analyzed. The median age was 46 years (range; 18-82). The most common final International Federation of Gynecology and Obstetrics 2009 stage was IB1, 474 patients (85%), and the most common histology was squamous carcinoma, 376 patients (67.6%). The 5-year disease-free survival was 93%, and the 10-year disease-free survival was 90%. The overall survival was 97% at 5 years and 89% at 10 years. During follow-up, 9% (n = 49) of patients experienced recurrences, 78% (n = 38) within the first 5 years. Comparing surgical approaches, 10-year disease-free survival was 92% for minimally invasive surgery and 88% for open surgery (p = .12). Similarly, 10-year overall survival was 92% for minimally invasive surgery and 88% for open surgery (p = .12). Post-recurrence disease-specific survival was 47% at 60 months and 39% at 96 months. The 2-year survival after recurrence was 80% for late recurrences (>5 years) versus 69% for early recurrences. Conclusions: The overall survival after radical hysterectomy at 5-years was 97% in patients with early-stage cervical cancer. The recurrence rate at 10 years was 9%. No differences in 10-year survival were observed between the surgical approaches.
KW - 10-Year Survival
KW - Cervical Cancer
KW - Disease-Free Survival
KW - Oncological Outcomes
KW - Radical Hysterectomy Outcomes
U2 - 10.1016/j.ijgc.2025.101690
DO - 10.1016/j.ijgc.2025.101690
M3 - Article
AN - SCOPUS:86000365312
SN - 1048-891X
VL - 35
JO - International Journal of Gynecological Cancer
JF - International Journal of Gynecological Cancer
IS - 5
M1 - 101690
ER -
