Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium

Nira Arad-Cohen; Bernward Zeller; Jonas Abrahamsson; Jose Maria Fernandez Navarro; Daniel Cheuk; Sauli Palmu; Vitor Costa; Barbara De Moerloose; Henrik Hasle; Kirsi Jahnukainen; Cornelis Jan Pronk; Ólafur Gísli Jónsson; Zhanna Kovalova; Birgitte Lausen; Monica Munthe-Kaas; Ulrika Noren-Nyström; Josefine Palle; Ramune Pasauliene; Kadri Saks; Gertjan Jl Kaspers

doi:10.1080/14737140.2022.2131544

Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium

Nira Arad-Cohen, Bernward Zeller, Jonas Abrahamsson, Jose Maria Fernandez Navarro, Daniel Cheuk, Sauli Palmu, Vitor Costa, Barbara De Moerloose, Henrik Hasle, Kirsi Jahnukainen, Cornelis Jan Pronk, Ólafur Gísli Jónsson, Zhanna Kovalova, Birgitte Lausen, Monica Munthe-Kaas, Ulrika Noren-Nyström, Josefine Palle, Ramune Pasauliene, Kadri Saks, Gertjan Jl Kaspers

Clinical Medicine

Research output: Contribution to journal › Review Article › peer-review

Abstract

INTRODUCTION: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications.

AREA COVERED: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.

EXPERT OPINION: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome.

Original language	English
Pages (from-to)	1183-1196
Number of pages	14
Journal	EXPERT REVIEW OF ANTICANCER THERAPY
Volume	22
Issue number	11
DOIs	https://doi.org/10.1080/14737140.2022.2131544
Publication status	Published - Nov 2022
Publication type	A2 Review article in a scientific journal

Keywords

Adolescent
Child
Humans
Leukemia, Myeloid, Acute/therapy
Typhlitis
Cardiotoxicity

Publication forum classification

Publication forum level 1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/14737140.2022.2131544

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Arad-Cohen, N., Zeller, B., Abrahamsson, J., Fernandez Navarro, J. M., Cheuk, D., Palmu, S., Costa, V., De Moerloose, B., Hasle, H., Jahnukainen, K., Pronk, C. J., Gísli Jónsson, Ó., Kovalova, Z., Lausen, B., Munthe-Kaas, M., Noren-Nyström, U., Palle, J., Pasauliene, R., Saks, K., & Kaspers, G. J. (2022). Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium. EXPERT REVIEW OF ANTICANCER THERAPY, 22(11), 1183-1196. https://doi.org/10.1080/14737140.2022.2131544

@article{527036298cd2464eabb62891b9457cfc,

title = "Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium",

abstract = "INTRODUCTION: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications.AREA COVERED: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.EXPERT OPINION: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome.",

keywords = "Adolescent, Child, Humans, Leukemia, Myeloid, Acute/therapy, Typhlitis, Cardiotoxicity",

author = "Nira Arad-Cohen and Bernward Zeller and Jonas Abrahamsson and {Fernandez Navarro}, {Jose Maria} and Daniel Cheuk and Sauli Palmu and Vitor Costa and {De Moerloose}, Barbara and Henrik Hasle and Kirsi Jahnukainen and Pronk, {Cornelis Jan} and {G{\'i}sli J{\'o}nsson}, {\'O}lafur and Zhanna Kovalova and Birgitte Lausen and Monica Munthe-Kaas and Ulrika Noren-Nystr{\"o}m and Josefine Palle and Ramune Pasauliene and Kadri Saks and Kaspers, {Gertjan Jl}",

year = "2022",

month = nov,

doi = "10.1080/14737140.2022.2131544",

language = "English",

volume = "22",

pages = "1183--1196",

journal = "EXPERT REVIEW OF ANTICANCER THERAPY",

issn = "1473-7140",

publisher = "Informa Healthcare",

number = "11",

}

Arad-Cohen, N, Zeller, B, Abrahamsson, J, Fernandez Navarro, JM, Cheuk, D, Palmu, S, Costa, V, De Moerloose, B, Hasle, H, Jahnukainen, K, Pronk, CJ, Gísli Jónsson, Ó, Kovalova, Z, Lausen, B, Munthe-Kaas, M, Noren-Nyström, U, Palle, J, Pasauliene, R, Saks, K & Kaspers, GJ 2022, 'Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium', EXPERT REVIEW OF ANTICANCER THERAPY, vol. 22, no. 11, pp. 1183-1196. https://doi.org/10.1080/14737140.2022.2131544

TY - JOUR

T1 - Supportive care in pediatric acute myeloid leukemia

T2 - Expert-based recommendations of the NOPHO-DB-SHIP consortium

AU - Arad-Cohen, Nira

AU - Zeller, Bernward

AU - Abrahamsson, Jonas

AU - Fernandez Navarro, Jose Maria

AU - Cheuk, Daniel

AU - Palmu, Sauli

AU - Costa, Vitor

AU - De Moerloose, Barbara

AU - Hasle, Henrik

AU - Jahnukainen, Kirsi

AU - Pronk, Cornelis Jan

AU - Gísli Jónsson, Ólafur

AU - Kovalova, Zhanna

AU - Lausen, Birgitte

AU - Munthe-Kaas, Monica

AU - Noren-Nyström, Ulrika

AU - Palle, Josefine

AU - Pasauliene, Ramune

AU - Saks, Kadri

AU - Kaspers, Gertjan Jl

PY - 2022/11

Y1 - 2022/11

N2 - INTRODUCTION: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications.AREA COVERED: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.EXPERT OPINION: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome.

AB - INTRODUCTION: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications.AREA COVERED: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.EXPERT OPINION: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome.

KW - Adolescent

KW - Child

KW - Humans

KW - Leukemia, Myeloid, Acute/therapy

KW - Typhlitis

KW - Cardiotoxicity

U2 - 10.1080/14737140.2022.2131544

DO - 10.1080/14737140.2022.2131544

M3 - Review Article

C2 - 36191604

SN - 1473-7140

VL - 22

SP - 1183

EP - 1196

JO - EXPERT REVIEW OF ANTICANCER THERAPY

JF - EXPERT REVIEW OF ANTICANCER THERAPY

IS - 11

ER -

Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium

Abstract

Keywords

Publication forum classification

UN SDGs

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