Supportive care in pediatric acute myeloid leukemia: Expert-based recommendations of the NOPHO-DB-SHIP consortium

Nira Arad-Cohen, Bernward Zeller, Jonas Abrahamsson, Jose Maria Fernandez Navarro, Daniel Cheuk, Sauli Palmu, Vitor Costa, Barbara De Moerloose, Henrik Hasle, Kirsi Jahnukainen, Cornelis Jan Pronk, Ólafur Gísli Jónsson, Zhanna Kovalova, Birgitte Lausen, Monica Munthe-Kaas, Ulrika Noren-Nyström, Josefine Palle, Ramune Pasauliene, Kadri Saks, Gertjan Jl Kaspers

    Research output: Contribution to journalReview Articlepeer-review


    INTRODUCTION: Pediatric acute myeloid leukemia (AML) is the second most common type of pediatric leukemia. Patients with AML are at high risk for several complications such as infections, typhlitis, and acute and long-term cardiotoxicity. Despite this knowledge, there are no definite supportive care guidelines as to what the best approach is to manage or prevent these complications.

    AREA COVERED: The NOPHO-DB-SHIP (Nordic-Dutch-Belgian-Spain-Hong-Kong-Israel-Portugal) consortium, in preparation for a new trial in pediatric AML patients, had dedicated meetings for supportive care. In this review, the authors discuss the available data and outline recommendations for the management of children and adolescents with AML with an emphasis on hyperleukocytosis, tumor lysis syndrome, coagulation abnormalities and bleeding, infection, typhlitis, malnutrition, cardiotoxicity, and fertility preservation.

    EXPERT OPINION: Improved supportive care has significantly contributed to increased cure rates. Recommendations on supportive care are an essential part of treatment for this highly susceptible population and will further improve their outcome.

    Original languageEnglish
    Pages (from-to)1183-1196
    Number of pages14
    Issue number11
    Publication statusPublished - Nov 2022
    Publication typeA2 Review article in a scientific journal


    • Adolescent
    • Child
    • Humans
    • Leukemia, Myeloid, Acute/therapy
    • Typhlitis
    • Cardiotoxicity

    Publication forum classification

    • Publication forum level 1


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