Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial Comparing Laser Surgery and Radiation Therapy

Pihla Pakkanen; Heikki Irjala; Taru Ilmarinen; Elina Halme; Paula Lindholm; Antti Mäkitie; Tuija Wigren; Leena Maija Aaltonen

doi:10.1016/j.ijrobp.2022.01.010

Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial Comparing Laser Surgery and Radiation Therapy

Pihla Pakkanen, Heikki Irjala, Taru Ilmarinen, Elina Halme, Paula Lindholm, Antti Mäkitie, Tuija Wigren, Leena Maija Aaltonen

Research output: Contribution to journal › Article › Scientific › peer-review

Abstract

Purpose: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our aim was to compare TLS and RT treatment results in a randomized study. Methods and Materials: Of 56 male patients with glottic T1a LSCC, 31 were randomized for TLS and 25 for RT. Survival and larynx preservation data were collected from medical records. Results: Five-year overall survival (OS) was 87%, disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 88% in patients treated with RT. The primary treatment method was not associated with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar in both groups (TLS, 97%; RT, 92%; P = .575). Conclusions: In a prospective randomized setting oncological outcomes of both treatment modalities (TLS or RT) for T1a LSCC were similar.

Original language	English
Pages (from-to)	96-100
Journal	INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume	113
Issue number	1
DOIs	https://doi.org/10.1016/j.ijrobp.2022.01.010
Publication status	Published - 2022
Publication type	A1 Journal article-refereed

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Radiation
Oncology
Radiology Nuclear Medicine and imaging
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ijrobp.2022.01.010

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@article{fe9780dec14142adb2f70b279e3fd10b,

title = "Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial Comparing Laser Surgery and Radiation Therapy",

abstract = "Purpose: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our aim was to compare TLS and RT treatment results in a randomized study. Methods and Materials: Of 56 male patients with glottic T1a LSCC, 31 were randomized for TLS and 25 for RT. Survival and larynx preservation data were collected from medical records. Results: Five-year overall survival (OS) was 87%, disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 88% in patients treated with RT. The primary treatment method was not associated with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar in both groups (TLS, 97%; RT, 92%; P = .575). Conclusions: In a prospective randomized setting oncological outcomes of both treatment modalities (TLS or RT) for T1a LSCC were similar.",

author = "Pihla Pakkanen and Heikki Irjala and Taru Ilmarinen and Elina Halme and Paula Lindholm and Antti M{\"a}kitie and Tuija Wigren and Aaltonen, {Leena Maija}",

note = "Funding Information: The study was funded by the Helsinki University Hospital research funds. Publisher Copyright: {\textcopyright} 2022 Elsevier Inc.",

year = "2022",

doi = "10.1016/j.ijrobp.2022.01.010",

language = "English",

volume = "113",

pages = "96--100",

journal = "INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS",

issn = "0360-3016",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Survival and Larynx Preservation in Early Glottic Cancer

T2 - A Randomized Trial Comparing Laser Surgery and Radiation Therapy

AU - Pakkanen, Pihla

AU - Irjala, Heikki

AU - Ilmarinen, Taru

AU - Halme, Elina

AU - Lindholm, Paula

AU - Mäkitie, Antti

AU - Wigren, Tuija

AU - Aaltonen, Leena Maija

PY - 2022

Y1 - 2022

N2 - Purpose: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our aim was to compare TLS and RT treatment results in a randomized study. Methods and Materials: Of 56 male patients with glottic T1a LSCC, 31 were randomized for TLS and 25 for RT. Survival and larynx preservation data were collected from medical records. Results: Five-year overall survival (OS) was 87%, disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 88% in patients treated with RT. The primary treatment method was not associated with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar in both groups (TLS, 97%; RT, 92%; P = .575). Conclusions: In a prospective randomized setting oncological outcomes of both treatment modalities (TLS or RT) for T1a LSCC were similar.

AB - Purpose: The prognosis of glottic T1a laryngeal squamous cell carcinoma (LSCC) is excellent with both transoral laser surgery (TLS) and radiation therapy (RT). Our aim was to compare TLS and RT treatment results in a randomized study. Methods and Materials: Of 56 male patients with glottic T1a LSCC, 31 were randomized for TLS and 25 for RT. Survival and larynx preservation data were collected from medical records. Results: Five-year overall survival (OS) was 87%, disease-specific survival (DSS) was 97%, and recurrence-free survival (RFS) was 81% in patients treated with TLS. Five-year OS was 92%, DSS was 100%, and RFS was 88% in patients treated with RT. The primary treatment method was not associated with OS, RFS, or DSS in a log-rank test. The larynx preservation rate was similar in both groups (TLS, 97%; RT, 92%; P = .575). Conclusions: In a prospective randomized setting oncological outcomes of both treatment modalities (TLS or RT) for T1a LSCC were similar.

U2 - 10.1016/j.ijrobp.2022.01.010

DO - 10.1016/j.ijrobp.2022.01.010

M3 - Article

AN - SCOPUS:85124484391

SN - 0360-3016

VL - 113

SP - 96

EP - 100

JO - INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

JF - INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

IS - 1

ER -

Survival and Larynx Preservation in Early Glottic Cancer: A Randomized Trial Comparing Laser Surgery and Radiation Therapy

Abstract

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ASJC Scopus subject areas

UN SDGs

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