Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles

Mattias Tengdelius; Deepanjali Gurav; Peter Konradsson; Peter Påhlsson; May Griffith; Oommen P. Oommen

doi:10.1039/C5CC02387D

Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles

Mattias Tengdelius, Deepanjali Gurav, Peter Konradsson, Peter Påhlsson, May Griffith, Oommen P. Oommen

Research output: Contribution to journal › Article › Scientific › peer-review

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Abstract

Gold nanoparticles coated with fucoidan-mimetic glycopolymers were
synthesized that displayed good colloidal stability and promising anticancer
properties. Fucoidan mimetic glycopolymers on their own were
nontoxic, while glycopolymer coated gold nanoparticles displayed
selective cytotoxicity to human colon cancer cell lines (HCT116) while
it was non-toxic to mouse fibroblast cells (NIH3T3).

Original language	English
Pages (from-to)	8532-8535
Journal	Chemical Communications
Volume	51
Issue number	40
DOIs	https://doi.org/10.1039/C5CC02387D
Publication status	Published - 10 Apr 2015
Publication type	A1 Journal article-refereed

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Publication forum level 2

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/C5CC02387D

c5cc02387d
This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Final published version, 1.7 MBLicence: CC BY

http://urn.fi/URN:NBN:fi:tty-201611284810

Cite this

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title = "Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles",

abstract = "Gold nanoparticles coated with fucoidan-mimetic glycopolymers weresynthesized that displayed good colloidal stability and promising anticancerproperties. Fucoidan mimetic glycopolymers on their own werenontoxic, while glycopolymer coated gold nanoparticles displayedselective cytotoxicity to human colon cancer cell lines (HCT116) whileit was non-toxic to mouse fibroblast cells (NIH3T3).",

author = "Mattias Tengdelius and Deepanjali Gurav and Peter Konradsson and Peter P{\aa}hlsson and May Griffith and Oommen, {Oommen P.}",

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language = "English",

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T1 - Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles

AU - Tengdelius, Mattias

AU - Gurav, Deepanjali

AU - Konradsson, Peter

AU - Påhlsson, Peter

AU - Griffith, May

AU - Oommen, Oommen P.

PY - 2015/4/10

Y1 - 2015/4/10

N2 - Gold nanoparticles coated with fucoidan-mimetic glycopolymers weresynthesized that displayed good colloidal stability and promising anticancerproperties. Fucoidan mimetic glycopolymers on their own werenontoxic, while glycopolymer coated gold nanoparticles displayedselective cytotoxicity to human colon cancer cell lines (HCT116) whileit was non-toxic to mouse fibroblast cells (NIH3T3).

AB - Gold nanoparticles coated with fucoidan-mimetic glycopolymers weresynthesized that displayed good colloidal stability and promising anticancerproperties. Fucoidan mimetic glycopolymers on their own werenontoxic, while glycopolymer coated gold nanoparticles displayedselective cytotoxicity to human colon cancer cell lines (HCT116) whileit was non-toxic to mouse fibroblast cells (NIH3T3).

U2 - 10.1039/C5CC02387D

DO - 10.1039/C5CC02387D

M3 - Article

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EP - 8535

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 40

ER -

Synthesis and Anticancer Properties of Fucoidan-Mimetic Glycopolymer Coated Gold Nanoparticles

Abstract

Publication forum classification

UN SDGs

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