Targeting Carbonic Anhydrase Isozymes in the Treatment of Neurological Disorders

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Abstract

Carbonic anhydrases (CAs) are widely expressed in the nervous system where they play important physiological roles. In the brain and other parts of the system, different isozymes show unique distribution patterns, some of them being present in neurons (CA II, V, VII, XIV), capillary endothelium (CA IV), microglia (CA III), choroid plexus (CA II, III, XII, XIV), astrocytes (CA II and V), oligodendrocytes (CA II and XIII), and myelin sheath (CA II). Nervous tissues also express three carbonic anhydrase-related proteins (CARP VIII, X, XI), which may be involved in the brain development processes. Future research is needed to define the exact roles of these highly conserved CA isoforms and to design novel treatment strategies for the diseases caused by defects or abnormal regulation of CARPs. Enzymatically active CA isozymes are known drug targets to treat various neurological disorders including epilepsy, acute mountain sickness, pseudotumor cerebri, and brain edema. In this review article, we describe how the clinically approved CA inhibitors are used for the treatment of these diseases.

Original languageEnglish
Title of host publicationThe Carbonic Anhydrases: Current and Emerging Therapeutic Targets
EditorsW. Richard Chegwidden, Nicholas D. Carter
Place of PublicationCham
PublisherSpringer
Pages103-120
Number of pages18
ISBN (Electronic)978-3-030-79511-5
ISBN (Print)978-3-030-79513-9
DOIs
Publication statusPublished - 2021
Publication typeA3 Book chapter

Publication series

NameProgress in Drug Research
Volume75
ISSN (Print)0071-786X
ISSN (Electronic)2297-4555

Keywords

  • Brain
  • Carbonic anhydrase
  • Drug
  • Expression
  • Inhibitor
  • Neurology

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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