The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study

Petri Kresanov; Juha Mykkänen; Markku Ahotupa; Mika Ala-Korpela; Markus Juonala; Jari Kaikkonen; Mika Kähönen; Terho Lehtimäki; Tommi Vasankari; Jorma Viikari; Olli T. Raitakari

doi:10.1016/j.freeradbiomed.2020.10.020

The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study

Petri Kresanov^*
, Juha Mykkänen
, Markku Ahotupa
, Mika Ala-Korpela
, Markus Juonala
, Jari Kaikkonen
, Mika Kähönen
, Terho Lehtimäki
, Tommi Vasankari
, Jorma Viikari
, Olli T. Raitakari

^*Corresponding author for this work

Department of Clinical Chemistry

Research output: Contribution to journal › Article › Scientific › peer-review

4 Citations (Scopus)

Abstract

Objective: Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide insights into the associations of lipoprotein lipid oxidation markers with lipoprotein subclasses at the population level, we investigated the associations of oxidized HDL lipids (oxHDL_lipids) and oxidized LDL lipids (oxLDL_lipids) with lipoprotein subclasses in a population-based cross-sectional study of 1395 Finnish adults ages 24–39 years. Methods: The analysis of oxidized lipids was based on the determination of the baseline level of conjugated dienes in lipoprotein lipids. A high-throughput nuclear magnetic resonance (NMR) platform was used to quantify circulating lipoprotein subclass concentrations and analyze their lipid compositions. Results: OxHDL_lipids were mainly not associated with lipoprotein subclass lipid concentrations and lipid composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference and age. OxLDL_lipids were associated with several markers of lipoprotein subclass lipid concentrations and composition after adjustment for Apolipoprotein-B (Apo-B), age and waist circumference. Several measures of HDL and LDL subclasses, including phospholipid and triglyceride composition, associated directly with oxLDL_lipids. Cholesterol ester and free cholesterol composition in HDL and LDL associated inversely with oxLDL_lipids. Conclusion: We conclude that these results do not support the idea that HDL's particle size or composition would reflect its functional capacity in the reverse transport of oxidized lipids. On the contrary, oxLDL_lipids were associated with the entire lipoprotein subclass profile, including numerous associations with the compositional descriptors of the particles. This is in line with the suggested role of LDL oxidation in atherogenesis.

Original language	English
Pages (from-to)	225-232
Journal	Free Radical Biology and Medicine
Volume	162
Early online date	21 Oct 2020
DOIs	https://doi.org/10.1016/j.freeradbiomed.2020.10.020
Publication status	Published - Jan 2021
Publication type	A1 Journal article-refereed

Funding

The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio , Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation; and The Paulo Foundation . MAK is holding a research grant from the Sigrid Juselius Foundation, Finland .

Keywords

Atherosclerosis
HDL
LDL
Oxidized lipids

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Physiology (medical)
Biochemistry

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10.1016/j.freeradbiomed.2020.10.020

https://erepo.uef.fi/handle/123456789/25689

Cite this

Kresanov, P., Mykkänen, J., Ahotupa, M., Ala-Korpela, M., Juonala, M., Kaikkonen, J., Kähönen, M., Lehtimäki, T., Vasankari, T., Viikari, J., & Raitakari, O. T. (2021). The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study. Free Radical Biology and Medicine, 162, 225-232. https://doi.org/10.1016/j.freeradbiomed.2020.10.020

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title = "The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study",

abstract = "Objective: Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide insights into the associations of lipoprotein lipid oxidation markers with lipoprotein subclasses at the population level, we investigated the associations of oxidized HDL lipids (oxHDLlipids) and oxidized LDL lipids (oxLDLlipids) with lipoprotein subclasses in a population-based cross-sectional study of 1395 Finnish adults ages 24–39 years. Methods: The analysis of oxidized lipids was based on the determination of the baseline level of conjugated dienes in lipoprotein lipids. A high-throughput nuclear magnetic resonance (NMR) platform was used to quantify circulating lipoprotein subclass concentrations and analyze their lipid compositions. Results: OxHDLlipids were mainly not associated with lipoprotein subclass lipid concentrations and lipid composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference and age. OxLDLlipids were associated with several markers of lipoprotein subclass lipid concentrations and composition after adjustment for Apolipoprotein-B (Apo-B), age and waist circumference. Several measures of HDL and LDL subclasses, including phospholipid and triglyceride composition, associated directly with oxLDLlipids. Cholesterol ester and free cholesterol composition in HDL and LDL associated inversely with oxLDLlipids. Conclusion: We conclude that these results do not support the idea that HDL's particle size or composition would reflect its functional capacity in the reverse transport of oxidized lipids. On the contrary, oxLDLlipids were associated with the entire lipoprotein subclass profile, including numerous associations with the compositional descriptors of the particles. This is in line with the suggested role of LDL oxidation in atherogenesis.",

keywords = "Atherosclerosis, HDL, LDL, Oxidized lipids",

author = "Petri Kresanov and Juha Mykk{\"a}nen and Markku Ahotupa and Mika Ala-Korpela and Markus Juonala and Jari Kaikkonen and Mika K{\"a}h{\"o}nen and Terho Lehtim{\"a}ki and Tommi Vasankari and Jorma Viikari and Raitakari, \{Olli T.\}",

note = "Funding Information: The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio , Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation; Yrj{\"o} Jahnsson Foundation; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation; and The Paulo Foundation . MAK is holding a research grant from the Sigrid Juselius Foundation, Finland . Publisher Copyright: {\textcopyright} 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

year = "2021",

month = jan,

doi = "10.1016/j.freeradbiomed.2020.10.020",

language = "English",

volume = "162",

pages = "225--232",

journal = "Free Radical Biology and Medicine",

issn = "0891-5849",

publisher = "Elsevier",

}

Kresanov, P, Mykkänen, J, Ahotupa, M, Ala-Korpela, M, Juonala, M, Kaikkonen, J, Kähönen, M , Lehtimäki, T , Vasankari, T, Viikari, J & Raitakari, OT 2021, 'The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study', Free Radical Biology and Medicine, vol. 162, pp. 225-232. https://doi.org/10.1016/j.freeradbiomed.2020.10.020

The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study. / Kresanov, Petri; Mykkänen, Juha; Ahotupa, Markku et al.
In: Free Radical Biology and Medicine, Vol. 162, 01.2021, p. 225-232.

Research output: Contribution to journal › Article › Scientific › peer-review

TY - JOUR

T1 - The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions

T2 - The Cardiovascular Risk in Young Finns Study

AU - Kresanov, Petri

AU - Mykkänen, Juha

AU - Ahotupa, Markku

AU - Ala-Korpela, Mika

AU - Juonala, Markus

AU - Kaikkonen, Jari

AU - Kähönen, Mika

AU - Lehtimäki, Terho

AU - Vasankari, Tommi

AU - Viikari, Jorma

AU - Raitakari, Olli T.

N1 - Funding Information: The Young Finns Study has been financially supported by the Academy of Finland : grants 322098 , 286284 , 134309 (Eye), 126925 , 121584 , 124282 , 129378 (Salve), 117787 (Gendi), and 41071 (Skidi); the Social Insurance Institution of Finland ; Competitive State Research Financing of the Expert Responsibility area of Kuopio , Tampere and Turku University Hospitals (grant X51001 ); Juho Vainio Foundation; Paavo Nurmi Foundation ; Finnish Foundation for Cardiovascular Research ; Finnish Cultural Foundation; The Sigrid Juselius Foundation ; Tampere Tuberculosis Foundation ; Emil Aaltonen Foundation; Yrjö Jahnsson Foundation; Signe and Ane Gyllenberg Foundation ; Diabetes Research Foundation of Finnish Diabetes Association ; EU Horizon 2020 (grant 755320 for TAXINOMISIS and grant 848146 for To Aition); European Research Council (grant 742927 for MULTIEPIGEN project); and Tampere University Hospital Supporting Foundation; and The Paulo Foundation . MAK is holding a research grant from the Sigrid Juselius Foundation, Finland . Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021/1

Y1 - 2021/1

N2 - Objective: Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide insights into the associations of lipoprotein lipid oxidation markers with lipoprotein subclasses at the population level, we investigated the associations of oxidized HDL lipids (oxHDLlipids) and oxidized LDL lipids (oxLDLlipids) with lipoprotein subclasses in a population-based cross-sectional study of 1395 Finnish adults ages 24–39 years. Methods: The analysis of oxidized lipids was based on the determination of the baseline level of conjugated dienes in lipoprotein lipids. A high-throughput nuclear magnetic resonance (NMR) platform was used to quantify circulating lipoprotein subclass concentrations and analyze their lipid compositions. Results: OxHDLlipids were mainly not associated with lipoprotein subclass lipid concentrations and lipid composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference and age. OxLDLlipids were associated with several markers of lipoprotein subclass lipid concentrations and composition after adjustment for Apolipoprotein-B (Apo-B), age and waist circumference. Several measures of HDL and LDL subclasses, including phospholipid and triglyceride composition, associated directly with oxLDLlipids. Cholesterol ester and free cholesterol composition in HDL and LDL associated inversely with oxLDLlipids. Conclusion: We conclude that these results do not support the idea that HDL's particle size or composition would reflect its functional capacity in the reverse transport of oxidized lipids. On the contrary, oxLDLlipids were associated with the entire lipoprotein subclass profile, including numerous associations with the compositional descriptors of the particles. This is in line with the suggested role of LDL oxidation in atherogenesis.

AB - Objective: Oxidation of low-density lipoprotein (LDL) may promote atherosclerosis, whereas the reverse transport of oxidized lipids by high-density lipoprotein (HDL) may contribute to atheroprotection. To provide insights into the associations of lipoprotein lipid oxidation markers with lipoprotein subclasses at the population level, we investigated the associations of oxidized HDL lipids (oxHDLlipids) and oxidized LDL lipids (oxLDLlipids) with lipoprotein subclasses in a population-based cross-sectional study of 1395 Finnish adults ages 24–39 years. Methods: The analysis of oxidized lipids was based on the determination of the baseline level of conjugated dienes in lipoprotein lipids. A high-throughput nuclear magnetic resonance (NMR) platform was used to quantify circulating lipoprotein subclass concentrations and analyze their lipid compositions. Results: OxHDLlipids were mainly not associated with lipoprotein subclass lipid concentrations and lipid composition after adjustment for Apolipoprotein-A1 (Apo-A1), waist circumference and age. OxLDLlipids were associated with several markers of lipoprotein subclass lipid concentrations and composition after adjustment for Apolipoprotein-B (Apo-B), age and waist circumference. Several measures of HDL and LDL subclasses, including phospholipid and triglyceride composition, associated directly with oxLDLlipids. Cholesterol ester and free cholesterol composition in HDL and LDL associated inversely with oxLDLlipids. Conclusion: We conclude that these results do not support the idea that HDL's particle size or composition would reflect its functional capacity in the reverse transport of oxidized lipids. On the contrary, oxLDLlipids were associated with the entire lipoprotein subclass profile, including numerous associations with the compositional descriptors of the particles. This is in line with the suggested role of LDL oxidation in atherogenesis.

KW - Atherosclerosis

KW - HDL

KW - LDL

KW - Oxidized lipids

U2 - 10.1016/j.freeradbiomed.2020.10.020

DO - 10.1016/j.freeradbiomed.2020.10.020

M3 - Article

C2 - 33098999

AN - SCOPUS:85094557924

SN - 0891-5849

VL - 162

SP - 225

EP - 232

JO - Free Radical Biology and Medicine

JF - Free Radical Biology and Medicine

ER -

Kresanov P, Mykkänen J, Ahotupa M, Ala-Korpela M, Juonala M, Kaikkonen J et al. The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study. Free Radical Biology and Medicine. 2021 Jan;162:225-232. Epub 2020 Oct 21. doi: 10.1016/j.freeradbiomed.2020.10.020

The associations of oxidized lipoprotein lipids with lipoprotein subclass particle concentrations and their lipid compositions: The Cardiovascular Risk in Young Finns Study

Abstract

Funding

Keywords

Publication forum classification

ASJC Scopus subject areas

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