The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Katrin Amunts; Markus Axer; Swati Banerjee; Lise Bitsch; Jan G. Bjaalie; Philipp Brauner; Andrea Brovelli; Navona Calarco; Marcel Carrere; Svenja Caspers; Christine J. Charvet; Sven Cichon; Roshan Cools; Irene Costantini; Egidio Ugo D’Angelo; Giulia De Bonis; Gustavo Deco; Javier DeFelipe; Alain Destexhe; Timo Dickscheid; Markus Diesmann; Emrah Düzel; Simon B. Eickhoff; Gaute Einevoll; Damian Eke; Andreas K. Engel; Alan C. Evans; Kathinka Evers; Nataliia Fedorchenko; Stephanie J. Forkel; Jan Fousek; Angela D. Friederici; Karl Friston; Stephen Furber; Liesbet Geris; Rainer Goebel; Onur Güntürkün; Aini Ismafairus Abd Hamid; Christina Herold; Claus C. Hilgetag; Sabine M. Hölter; Yannis Ioannidis; Viktor Jirsa; Sriranga Kashyap; Burkhard S. Kasper; Alban de Kerchove d’Exaerde; Roxana Kooijmans; István Koren; Jeanette Hellgren Kotaleski; Gregory Kiar; Wouter Klijn; Lars Klüver; Alois C. Knoll; Zeljka Krsnik; Julia Kämpfer; Matthew E Larkum; Marja-Leena Linne; Thomas Lippert; Jafri Malin Abdullah; Paola Di Maio; Neville Magielse; Pierre Maquet; Anna Letizia Allegra Mascaro; Daniele Marinazzo; Jorge Mejias; Andreas Meyer-Lindenberg; Michele Migliore; Judith Michael; Yannick Morel; Fabrice O. Morin; Lars Muckli; Guy Nagels; Lena Oden; Nicola Palomero-Gallagher; Fanis Panagiotaropoulos; Pier Stanislao Paolucci; Cyriel Pennartz; Liesbet M. Peeters; Spase Petkoski; Nicolai Petkov; Lucy S. Petro; Mihai A. Petrovici; Giovanni Pezzulo; Pieter Roelfsema; Laurence Ris; Petra Ritter; Kathleen Rockland; Stefan Rotter; Andreas Rowald; Sabine Ruland; Philippe Ryvlin; Arleen Salles; Maria V. Sanchez-Vives; Johannes Schemmel; Walter Senn; Alexandra A. de Sousa; Felix Ströckens; Bertrand Thirion; Kâmil Uludağ; Simo Vanni; Sacha Jennifer van Albada; Wim Vanduffel; Julien Vezoli; Lisa Vincenz-Donnelly; Florian Walter; Laszlo Zaborszky

doi:10.1162/imag_a_00137

The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

Katrin Amunts, Markus Axer, Swati Banerjee, Lise Bitsch, Jan G. Bjaalie, Philipp Brauner, Andrea Brovelli, Navona Calarco, Marcel Carrere, Svenja Caspers, Christine J. Charvet, Sven Cichon, Roshan Cools, Irene Costantini, Egidio Ugo D’Angelo, Giulia De Bonis, Gustavo Deco, Javier DeFelipe, Alain Destexhe, Timo DickscheidMarkus Diesmann, Emrah Düzel, Simon B. Eickhoff, Gaute Einevoll, Damian Eke, Andreas K. Engel, Alan C. Evans, Kathinka Evers, Nataliia Fedorchenko, Stephanie J. Forkel, Jan Fousek, Angela D. Friederici, Karl Friston, Stephen Furber, Liesbet Geris, Rainer Goebel, Onur Güntürkün, Aini Ismafairus Abd Hamid, Christina Herold, Claus C. Hilgetag, Sabine M. Hölter, Yannis Ioannidis, Viktor Jirsa, Sriranga Kashyap, Burkhard S. Kasper, Alban de Kerchove d’Exaerde, Roxana Kooijmans, István Koren, Jeanette Hellgren Kotaleski, Gregory Kiar, Wouter Klijn, Lars Klüver, Alois C. Knoll, Zeljka Krsnik, Julia Kämpfer, Matthew E Larkum, Marja-Leena Linne, Thomas Lippert, Jafri Malin Abdullah, Paola Di Maio, Neville Magielse, Pierre Maquet, Anna Letizia Allegra Mascaro, Daniele Marinazzo, Jorge Mejias, Andreas Meyer-Lindenberg, Michele Migliore, Judith Michael, Yannick Morel, Fabrice O. Morin, Lars Muckli, Guy Nagels, Lena Oden, Nicola Palomero-Gallagher, Fanis Panagiotaropoulos, Pier Stanislao Paolucci, Cyriel Pennartz, Liesbet M. Peeters, Spase Petkoski, Nicolai Petkov, Lucy S. Petro, Mihai A. Petrovici, Giovanni Pezzulo, Pieter Roelfsema, Laurence Ris, Petra Ritter, Kathleen Rockland, Stefan Rotter, Andreas Rowald, Sabine Ruland, Philippe Ryvlin, Arleen Salles, Maria V. Sanchez-Vives, Johannes Schemmel, Walter Senn, Alexandra A. de Sousa, Felix Ströckens, Bertrand Thirion, Kâmil Uludağ, Simo Vanni, Sacha Jennifer van Albada, Wim Vanduffel, Julien Vezoli, Lisa Vincenz-Donnelly, Florian Walter, Laszlo Zaborszky

Biomedicine

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Abstract

In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP’s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.

Original language	English
Pages (from-to)	1-35
Number of pages	35
Journal	Imaging Neuroscience
Volume	2
DOIs	https://doi.org/10.1162/imag_a_00137
Publication status	Published - 2024
Publication type	A1 Journal article-refereed

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10.1162/imag_a_00137Licence: CC BY

imag_a_00137Final published version, 1.09 MBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-202405155893Licence: CC BY

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Amunts, K., Axer, M., Banerjee, S., Bitsch, L., Bjaalie, J. G., Brauner, P., Brovelli, A., Calarco, N., Carrere, M., Caspers, S., Charvet, C. J., Cichon, S., Cools, R., Costantini, I., D’Angelo, E. U., De Bonis, G., Deco, G., DeFelipe, J., Destexhe, A., ... Zaborszky, L. (2024). The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing. Imaging Neuroscience, 2, 1-35. https://doi.org/10.1162/imag_a_00137

@article{d718f3ba143343628e93dad598e45af4,

title = "The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing",

abstract = "In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe{\textquoteright}s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade{\textquoteright}s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP{\textquoteright}s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.",

author = "Katrin Amunts and Markus Axer and Swati Banerjee and Lise Bitsch and Bjaalie, {Jan G.} and Philipp Brauner and Andrea Brovelli and Navona Calarco and Marcel Carrere and Svenja Caspers and Charvet, {Christine J.} and Sven Cichon and Roshan Cools and Irene Costantini and D{\textquoteright}Angelo, {Egidio Ugo} and {De Bonis}, Giulia and Gustavo Deco and Javier DeFelipe and Alain Destexhe and Timo Dickscheid and Markus Diesmann and Emrah D{\"u}zel and Eickhoff, {Simon B.} and Gaute Einevoll and Damian Eke and Engel, {Andreas K.} and Evans, {Alan C.} and Kathinka Evers and Nataliia Fedorchenko and Forkel, {Stephanie J.} and Jan Fousek and Friederici, {Angela D.} and Karl Friston and Stephen Furber and Liesbet Geris and Rainer Goebel and Onur G{\"u}nt{\"u}rk{\"u}n and Hamid, {Aini Ismafairus Abd} and Christina Herold and Hilgetag, {Claus C.} and H{\"o}lter, {Sabine M.} and Yannis Ioannidis and Viktor Jirsa and Sriranga Kashyap and Kasper, {Burkhard S.} and d{\textquoteright}Exaerde, {Alban de Kerchove} and Roxana Kooijmans and Istv{\'a}n Koren and Kotaleski, {Jeanette Hellgren} and Gregory Kiar and Wouter Klijn and Lars Kl{\"u}ver and Knoll, {Alois C.} and Zeljka Krsnik and Julia K{\"a}mpfer and Larkum, {Matthew E} and Marja-Leena Linne and Thomas Lippert and Abdullah, {Jafri Malin} and Maio, {Paola Di} and Neville Magielse and Pierre Maquet and Mascaro, {Anna Letizia Allegra} and Daniele Marinazzo and Jorge Mejias and Andreas Meyer-Lindenberg and Michele Migliore and Judith Michael and Yannick Morel and Morin, {Fabrice O.} and Lars Muckli and Guy Nagels and Lena Oden and Nicola Palomero-Gallagher and Fanis Panagiotaropoulos and Paolucci, {Pier Stanislao} and Cyriel Pennartz and Peeters, {Liesbet M.} and Spase Petkoski and Nicolai Petkov and Petro, {Lucy S.} and Petrovici, {Mihai A.} and Giovanni Pezzulo and Pieter Roelfsema and Laurence Ris and Petra Ritter and Kathleen Rockland and Stefan Rotter and Andreas Rowald and Sabine Ruland and Philippe Ryvlin and Arleen Salles and Sanchez-Vives, {Maria V.} and Johannes Schemmel and Walter Senn and {de Sousa}, {Alexandra A.} and Felix Str{\"o}ckens and Bertrand Thirion and K{\^a}mil Uludağ and Simo Vanni and {van Albada}, {Sacha Jennifer} and Wim Vanduffel and Julien Vezoli and Lisa Vincenz-Donnelly and Florian Walter and Laszlo Zaborszky",

year = "2024",

doi = "10.1162/imag_a_00137",

language = "English",

volume = "2",

pages = "1--35",

}

Amunts, K, Axer, M, Banerjee, S, Bitsch, L, Bjaalie, JG, Brauner, P, Brovelli, A, Calarco, N, Carrere, M, Caspers, S, Charvet, CJ, Cichon, S, Cools, R, Costantini, I, D’Angelo, EU, De Bonis, G, Deco, G, DeFelipe, J, Destexhe, A, Dickscheid, T, Diesmann, M, Düzel, E, Eickhoff, SB, Einevoll, G, Eke, D, Engel, AK, Evans, AC, Evers, K, Fedorchenko, N, Forkel, SJ, Fousek, J, Friederici, AD, Friston, K, Furber, S, Geris, L, Goebel, R, Güntürkün, O, Hamid, AIA, Herold, C, Hilgetag, CC, Hölter, SM, Ioannidis, Y, Jirsa, V, Kashyap, S, Kasper, BS, d’Exaerde, ADK, Kooijmans, R, Koren, I, Kotaleski, JH, Kiar, G, Klijn, W, Klüver, L, Knoll, AC, Krsnik, Z, Kämpfer, J, Larkum, ME, Linne, M-L, Lippert, T, Abdullah, JM, Maio, PD, Magielse, N, Maquet, P, Mascaro, ALA, Marinazzo, D, Mejias, J, Meyer-Lindenberg, A, Migliore, M, Michael, J, Morel, Y, Morin, FO, Muckli, L, Nagels, G, Oden, L, Palomero-Gallagher, N, Panagiotaropoulos, F, Paolucci, PS, Pennartz, C, Peeters, LM, Petkoski, S, Petkov, N, Petro, LS, Petrovici, MA, Pezzulo, G, Roelfsema, P, Ris, L, Ritter, P, Rockland, K, Rotter, S, Rowald, A, Ruland, S, Ryvlin, P, Salles, A, Sanchez-Vives, MV, Schemmel, J, Senn, W, de Sousa, AA, Ströckens, F, Thirion, B, Uludağ, K, Vanni, S, van Albada, SJ, Vanduffel, W, Vezoli, J, Vincenz-Donnelly, L, Walter, F & Zaborszky, L 2024, 'The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing', Imaging Neuroscience, vol. 2, pp. 1-35. https://doi.org/10.1162/imag_a_00137

TY - JOUR

T1 - The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

AU - Amunts, Katrin

AU - Axer, Markus

AU - Banerjee, Swati

AU - Bitsch, Lise

AU - Bjaalie, Jan G.

AU - Brauner, Philipp

AU - Brovelli, Andrea

AU - Calarco, Navona

AU - Carrere, Marcel

AU - Caspers, Svenja

AU - Charvet, Christine J.

AU - Cichon, Sven

AU - Cools, Roshan

AU - Costantini, Irene

AU - D’Angelo, Egidio Ugo

AU - De Bonis, Giulia

AU - Deco, Gustavo

AU - DeFelipe, Javier

AU - Destexhe, Alain

AU - Dickscheid, Timo

AU - Diesmann, Markus

AU - Düzel, Emrah

AU - Eickhoff, Simon B.

AU - Einevoll, Gaute

AU - Eke, Damian

AU - Engel, Andreas K.

AU - Evans, Alan C.

AU - Evers, Kathinka

AU - Fedorchenko, Nataliia

AU - Forkel, Stephanie J.

AU - Fousek, Jan

AU - Friederici, Angela D.

AU - Friston, Karl

AU - Furber, Stephen

AU - Geris, Liesbet

AU - Goebel, Rainer

AU - Güntürkün, Onur

AU - Hamid, Aini Ismafairus Abd

AU - Herold, Christina

AU - Hilgetag, Claus C.

AU - Hölter, Sabine M.

AU - Ioannidis, Yannis

AU - Jirsa, Viktor

AU - Kashyap, Sriranga

AU - Kasper, Burkhard S.

AU - d’Exaerde, Alban de Kerchove

AU - Kooijmans, Roxana

AU - Koren, István

AU - Kotaleski, Jeanette Hellgren

AU - Kiar, Gregory

AU - Klijn, Wouter

AU - Klüver, Lars

AU - Knoll, Alois C.

AU - Krsnik, Zeljka

AU - Kämpfer, Julia

AU - Larkum, Matthew E

AU - Linne, Marja-Leena

AU - Lippert, Thomas

AU - Abdullah, Jafri Malin

AU - Maio, Paola Di

AU - Magielse, Neville

AU - Maquet, Pierre

AU - Mascaro, Anna Letizia Allegra

AU - Marinazzo, Daniele

AU - Mejias, Jorge

AU - Meyer-Lindenberg, Andreas

AU - Migliore, Michele

AU - Michael, Judith

AU - Morel, Yannick

AU - Morin, Fabrice O.

AU - Muckli, Lars

AU - Nagels, Guy

AU - Oden, Lena

AU - Palomero-Gallagher, Nicola

AU - Panagiotaropoulos, Fanis

AU - Paolucci, Pier Stanislao

AU - Pennartz, Cyriel

AU - Peeters, Liesbet M.

AU - Petkoski, Spase

AU - Petkov, Nicolai

AU - Petro, Lucy S.

AU - Petrovici, Mihai A.

AU - Pezzulo, Giovanni

AU - Roelfsema, Pieter

AU - Ris, Laurence

AU - Ritter, Petra

AU - Rockland, Kathleen

AU - Rotter, Stefan

AU - Rowald, Andreas

AU - Ruland, Sabine

AU - Ryvlin, Philippe

AU - Salles, Arleen

AU - Sanchez-Vives, Maria V.

AU - Schemmel, Johannes

AU - Senn, Walter

AU - de Sousa, Alexandra A.

AU - Ströckens, Felix

AU - Thirion, Bertrand

AU - Uludağ, Kâmil

AU - Vanni, Simo

AU - van Albada, Sacha Jennifer

AU - Vanduffel, Wim

AU - Vezoli, Julien

AU - Vincenz-Donnelly, Lisa

AU - Walter, Florian

AU - Zaborszky, Laszlo

PY - 2024

Y1 - 2024

N2 - In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP’s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.

AB - In recent years, brain research has indisputably entered a new epoch, driven by substantial methodological advances and digitally enabled data integration and modelling at multiple scales—from molecules to the whole brain. Major advances are emerging at the intersection of neuroscience with technology and computing. This new science of the brain combines high-quality research, data integration across multiple scales, a new culture of multidisciplinary large-scale collaboration, and translation into applications. As pioneered in Europe’s Human Brain Project (HBP), a systematic approach will be essential for meeting the coming decade’s pressing medical and technological challenges. The aims of this paper are to: develop a concept for the coming decade of digital brain research, discuss this new concept with the research community at large, identify points of convergence, and derive therefrom scientific common goals; provide a scientific framework for the current and future development of EBRAINS, a research infrastructure resulting from the HBP’s work; inform and engage stakeholders, funding organisations and research institutions regarding future digital brain research; identify and address the transformational potential of comprehensive brain models for artificial intelligence, including machine learning and deep learning; outline a collaborative approach that integrates reflection, dialogues, and societal engagement on ethical and societal opportunities and challenges as part of future neuroscience research.

U2 - 10.1162/imag_a_00137

DO - 10.1162/imag_a_00137

M3 - Article

SN - 2837-6056

VL - 2

SP - 1

EP - 35

JO - Imaging Neuroscience

JF - Imaging Neuroscience

ER -

The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing

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