The effect of lipid oxidation on the water permeability of phospholipids bilayers

Mateusz Lis; Alicja Wizert; Magda Przybylo; Marek Langner; Jerzy Swiatek; Pavel Jungwirth; Lukasz Cwiklik

doi:10.1039/c1cp21009b

The effect of lipid oxidation on the water permeability of phospholipids bilayers

Mateusz Lis
, Alicja Wizert
, Magda Przybylo
, Marek Langner
, Jerzy Swiatek
, Pavel Jungwirth
, Lukasz Cwiklik^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

96 Citations (Scopus)

Abstract

The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is

Original language	English
Pages (from-to)	17555-17563
Number of pages	9
Journal	Physical Chemistry Chemical Physics
Volume	13
Issue number	39
DOIs	https://doi.org/10.1039/c1cp21009b
Publication status	Published - 21 Oct 2011
Publication type	A1 Journal article-refereed

ASJC Scopus subject areas

Physical and Theoretical Chemistry
General Physics and Astronomy

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abstract = "The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol\%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol\% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol\% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is",

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T1 - The effect of lipid oxidation on the water permeability of phospholipids bilayers

AU - Lis, Mateusz

AU - Wizert, Alicja

AU - Przybylo, Magda

AU - Langner, Marek

AU - Swiatek, Jerzy

AU - Jungwirth, Pavel

AU - Cwiklik, Lukasz

PY - 2011/10/21

Y1 - 2011/10/21

N2 - The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is

AB - The effect of lipid oxidation on water permeability of phosphatidylcholine membranes was investigated by means of both scattering stopped flow experiments and atomistic molecular dynamics simulations. Formation of water pores followed by a significant enhancement of water permeability was observed. The molecules of oxidized phospholipids facilitate pore formation and subsequently stabilize water in the membrane interior. A wide range of oxidation ratios, from 15 to 100 mol%, was considered. The degree of oxidation was found to strongly influence the time needed for the opening of a pore. In simulations, the oxidation ratio of 75 mol% was found to be a threshold for spontaneous pore formation in the tens of nanosecond timescale, whereas 15 mol% of oxidation led to significant water permeation in the timescale of seconds. Once a pore was formed, the water permeability was found to be virtually independent of the oxidation ratio. This journal is

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JO - Physical Chemistry Chemical Physics

JF - Physical Chemistry Chemical Physics

IS - 39

ER -

The effect of lipid oxidation on the water permeability of phospholipids bilayers

Abstract

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