The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

Sanni Tervo, Miia Seppälä, Markus Rautiainen, Heini Huhtala, Tuula Salo, Ahmed Al-Samadi, Teijo Kuopio, Maarit Ahtiainen, Satu Tommola, Timo Paavonen, Sanna Toppila-Salmi

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.

Original languageEnglish
Pages (from-to)626-636
Number of pages11
JournalAPMIS
Volume128
Issue number12
DOIs
Publication statusPublished - 1 Dec 2020
Publication typeA1 Journal article-refereed

Keywords

  • immunohistochemistry
  • molecular marker
  • prognosis
  • Programmed cell death protein 1 (PD-1)
  • tongue squamous cell carcinoma

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Immunology and Allergy
  • Microbiology (medical)

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