The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

Sanni Tervo; Miia Seppälä; Markus Rautiainen; Heini Huhtala; Tuula Salo; Ahmed Al-Samadi; Teijo Kuopio; Maarit Ahtiainen; Satu Tommola; Timo Paavonen; Sanna Toppila-Salmi

doi:10.1111/apm.13084

The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

Sanni Tervo^*
, Miia Seppälä
, Markus Rautiainen
, Heini Huhtala
, Tuula Salo
, Ahmed Al-Samadi
, Teijo Kuopio
, Maarit Ahtiainen
, Satu Tommola
, Timo Paavonen
, Sanna Toppila-Salmi

^*Corresponding author for this work

Research output: Contribution to journal › Article › Scientific › peer-review

2 Citations (Scopus)

Abstract

Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.

Original language	English
Pages (from-to)	626-636
Number of pages	11
Journal	APMIS
Volume	128
Issue number	12
DOIs	https://doi.org/10.1111/apm.13084
Publication status	Published - 1 Dec 2020
Publication type	A1 Journal article-refereed

Funding

The study was supported in part by research grants from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, the Helsinki University Central Hospital Research Fund, Tampere Tuberculosis association, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, Jane and Aatos Erkko Foundation, Paulo Foundation, Yrjö Jahnsson Foundation, Foundation of the Finnish Anti‐Tuberculosis Association and Väinö and Laina Kivi Foundation. The authors report no conflicts of interest.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

immunohistochemistry
molecular marker
prognosis
Programmed cell death protein 1 (PD-1)
tongue squamous cell carcinoma

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Pathology and Forensic Medicine
Immunology and Allergy
Microbiology (medical)

Access to Document

10.1111/apm.13084

http://urn.fi/URN:NBN:fi:jyu-202010016038

Cite this

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title = "The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma",

abstract = "Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.",

keywords = "immunohistochemistry, molecular marker, prognosis, Programmed cell death protein 1 (PD-1), tongue squamous cell carcinoma",

author = "Sanni Tervo and Miia Sepp{\"a}l{\"a} and Markus Rautiainen and Heini Huhtala and Tuula Salo and Ahmed Al-Samadi and Teijo Kuopio and Maarit Ahtiainen and Satu Tommola and Timo Paavonen and Sanna Toppila-Salmi",

note = "Funding Information: The study was supported in part by research grants from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, the Helsinki University Central Hospital Research Fund, Tampere Tuberculosis association, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, Jane and Aatos Erkko Foundation, Paulo Foundation, Yrj{\"o} Jahnsson Foundation, Foundation of the Finnish Anti‐Tuberculosis Association and V{\"a}in{\"o} and Laina Kivi Foundation. The authors report no conflicts of interest. Publisher Copyright: {\textcopyright} 2020 Scandinavian Societies for Medical Microbiology and Pathology Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",

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doi = "10.1111/apm.13084",

language = "English",

volume = "128",

pages = "626--636",

journal = "APMIS",

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T1 - The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

AU - Tervo, Sanni

AU - Seppälä, Miia

AU - Rautiainen, Markus

AU - Huhtala, Heini

AU - Salo, Tuula

AU - Al-Samadi, Ahmed

AU - Kuopio, Teijo

AU - Ahtiainen, Maarit

AU - Tommola, Satu

AU - Paavonen, Timo

AU - Toppila-Salmi, Sanna

N1 - Funding Information: The study was supported in part by research grants from the Competitive State Research Financing of the Expert Responsibility area of Tampere University Hospital, the Helsinki University Central Hospital Research Fund, Tampere Tuberculosis association, the Finnish Association of Otorhinolaryngology and Head and Neck Surgery, Jane and Aatos Erkko Foundation, Paulo Foundation, Yrjö Jahnsson Foundation, Foundation of the Finnish Anti‐Tuberculosis Association and Väinö and Laina Kivi Foundation. The authors report no conflicts of interest. Publisher Copyright: © 2020 Scandinavian Societies for Medical Microbiology and Pathology Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.

AB - Programmed cell death protein 1 (PD-1) is an immune checkpoint receptor which plays an important role in a patient's immune responses to microbial and cancer antigens. It is expressed in tumor-infiltrating lymphocytes (TILs) with many different malignancies. The aim of the study was to evaluate PD-1 expression and its prognostic value in tongue cancer. The data of tongue squamous cell carcinoma (TSCC) patients (N = 81) treated in Tampere University Hospital between 1999 and 2013 were used. Control data consisted of patients with non-malignant tongue mucous membrane lesions (N = 48). The formalin-fixed paraffin-embedded samples were stained immunohistochemically and scanned via digital microscope. The staining of PD-1 was examined semi-quantitatively. The density and intensity of PD-1 + cells were significantly higher in TSCC than in control samples. The expression of PD-1 correlated with better survival. The expression of PD-1 could be a potential prognostic marker in TSCC. Further research using larger sample size is needed.

KW - immunohistochemistry

KW - molecular marker

KW - prognosis

KW - Programmed cell death protein 1 (PD-1)

KW - tongue squamous cell carcinoma

U2 - 10.1111/apm.13084

DO - 10.1111/apm.13084

M3 - Article

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SN - 0903-4641

VL - 128

SP - 626

EP - 636

JO - APMIS

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IS - 12

ER -

The expression and prognostic relevance of programmed cell death protein 1 in tongue squamous cell carcinoma

Abstract

Funding

UN SDGs

Keywords

Publication forum classification

ASJC Scopus subject areas

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