The glycosphingolipids of human prostate tissue

T. Shiraishi; M. T. Kinter; S. E. Mills; M. C. Lippert; G. S. Bova; W. W. Young

doi:10.1016/0005-2760(88)90109-9

The glycosphingolipids of human prostate tissue

T. Shiraishi, M. T. Kinter, S. E. Mills, M. C. Lippert, G. S. Bova, W. W. Young

Research output: Contribution to journal › Article › Scientific › peer-review

4 Citations (Scopus)

Abstract

Neutral glycolipids and gangliosides from surgical samples of benign human prostate tissue were analyzed by chemical, enzymatic and immunostaining procedures. The neutral glycolipids consisted of ceramide mono-, di-, tri- and tetrahexosides of the globo series plus paragloboside. The monosialoganglioside fraction contained G_M3 and G_M1 plus multiple species of monosialylated lactosamine-containing structures, including sialyl-α-2 → 3paragloboside plus at least two compounds having a non-reducing terminal sialyl α2 → 6Gal linkage. The disialoganglioside fraction contained G_D3 as the major component plus G_D1a, G_D2 and G_D1b. G_T1b was the major trisialoganglioside.

Original language	English
Pages (from-to)	160-169
Number of pages	10
Journal	Biochimica et Biophysica Acta (BBA)/Lipids and Lipid Metabolism
Volume	961
Issue number	2
DOIs	https://doi.org/10.1016/0005-2760(88)90109-9
Publication status	Published - 22 Jul 1988
Externally published	Yes
Publication type	A1 Journal article-refereed

Keywords

(Human)
Ganglioside
Glycosphingolipid
Prostate

ASJC Scopus subject areas

Biophysics
Biochemistry
Endocrinology

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10.1016/0005-2760(88)90109-9

Cite this

@article{78f267f9418441f7a3a22ed1ab025560,

title = "The glycosphingolipids of human prostate tissue",

abstract = "Neutral glycolipids and gangliosides from surgical samples of benign human prostate tissue were analyzed by chemical, enzymatic and immunostaining procedures. The neutral glycolipids consisted of ceramide mono-, di-, tri- and tetrahexosides of the globo series plus paragloboside. The monosialoganglioside fraction contained GM3 and GM1 plus multiple species of monosialylated lactosamine-containing structures, including sialyl-α-2 → 3paragloboside plus at least two compounds having a non-reducing terminal sialyl α2 → 6Gal linkage. The disialoganglioside fraction contained GD3 as the major component plus GD1a, GD2 and GD1b. GT1b was the major trisialoganglioside.",

keywords = "(Human), Ganglioside, Glycosphingolipid, Prostate",

author = "T. Shiraishi and Kinter, {M. T.} and Mills, {S. E.} and Lippert, {M. C.} and Bova, {G. S.} and Young, {W. W.}",

note = "Funding Information: This investigation was supported by a grant from the Research and Development Committee, University of Virginia and grant PDT 335 from the American Cancer Society. The authors thank the following persons for their kind donations of glycolipids and monoclonal antibodies: Drs. D. Cheresh, S. Hakomori, S. Gross, and T.E. Thompson.",

year = "1988",

month = jul,

day = "22",

doi = "10.1016/0005-2760(88)90109-9",

language = "English",

volume = "961",

pages = "160--169",

number = "2",

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TY - JOUR

T1 - The glycosphingolipids of human prostate tissue

AU - Shiraishi, T.

AU - Kinter, M. T.

AU - Mills, S. E.

AU - Lippert, M. C.

AU - Bova, G. S.

AU - Young, W. W.

N1 - Funding Information: This investigation was supported by a grant from the Research and Development Committee, University of Virginia and grant PDT 335 from the American Cancer Society. The authors thank the following persons for their kind donations of glycolipids and monoclonal antibodies: Drs. D. Cheresh, S. Hakomori, S. Gross, and T.E. Thompson.

PY - 1988/7/22

Y1 - 1988/7/22

N2 - Neutral glycolipids and gangliosides from surgical samples of benign human prostate tissue were analyzed by chemical, enzymatic and immunostaining procedures. The neutral glycolipids consisted of ceramide mono-, di-, tri- and tetrahexosides of the globo series plus paragloboside. The monosialoganglioside fraction contained GM3 and GM1 plus multiple species of monosialylated lactosamine-containing structures, including sialyl-α-2 → 3paragloboside plus at least two compounds having a non-reducing terminal sialyl α2 → 6Gal linkage. The disialoganglioside fraction contained GD3 as the major component plus GD1a, GD2 and GD1b. GT1b was the major trisialoganglioside.

AB - Neutral glycolipids and gangliosides from surgical samples of benign human prostate tissue were analyzed by chemical, enzymatic and immunostaining procedures. The neutral glycolipids consisted of ceramide mono-, di-, tri- and tetrahexosides of the globo series plus paragloboside. The monosialoganglioside fraction contained GM3 and GM1 plus multiple species of monosialylated lactosamine-containing structures, including sialyl-α-2 → 3paragloboside plus at least two compounds having a non-reducing terminal sialyl α2 → 6Gal linkage. The disialoganglioside fraction contained GD3 as the major component plus GD1a, GD2 and GD1b. GT1b was the major trisialoganglioside.

KW - (Human)

KW - Ganglioside

KW - Glycosphingolipid

KW - Prostate

U2 - 10.1016/0005-2760(88)90109-9

DO - 10.1016/0005-2760(88)90109-9

M3 - Article

C2 - 3390453

AN - SCOPUS:0023683831

VL - 961

SP - 160

EP - 169

IS - 2

ER -

The glycosphingolipids of human prostate tissue

Abstract

Keywords

ASJC Scopus subject areas

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