The Role of Milk Protein and Whey Permeate in Lipid-based Nutrient Supplements on the Growth and Development of Stunted Children in Uganda: A Randomized Trial Protocol (MAGNUS)

Hannah Pesu, Rolland Mutumba, Joseph Mbabazi, Mette F. Olsen, Christian Mølgaard, Kim F. Michaelsen, Christian Ritz, Suzanne Filteau, André Briend, Ezekiel Mupere, Henrik Friis, Benedikte Grenov

Research output: Contribution to journalArticleScientificpeer-review

Abstract

Stunting is associated with cognitive impairment and later chronic disease. Previous trials to prevent stunting have had little effect, and no trials seem to have provided larger amounts of energy and high-quality proteins to already stunted children. We aimed to assess the effects of milk protein (MP) and whey permeate (WP) in large-quantity lipid-based nutrient supplements (LNS-LQ), among stunted children, on linear growth and child development. This was a randomized, double-blind, 2-by-2 factorial trial. Stunted children aged 12-59 mo from eastern Uganda (n = 750) were randomly assigned to receive 100 g LNS-LQ with or without MP and WP (n = 4 × 150) or no supplement (n = 150) for 3 mo. The primary outcomes were change in knee-heel and total length. Secondary outcomes included child development, body composition, anthropometry, and hemoglobin. Micronutrient status, intestinal function, and microbiota were also assessed. Our findings will contribute to an understanding of the role of milk ingredients and LNS in linear catch-up growth. This trial was registered at www.isrctn.com as ISRCTN13093195.

Original languageEnglish
Article numbernzab067
JournalCurrent Developments in Nutrition
Volume5
Issue number5
DOIs
Publication statusPublished - 1 May 2021
Publication typeA1 Journal article-refereed

Keywords

  • body composition
  • child development
  • gut
  • linear growth
  • lipid-based nutrient supplement (LNS)
  • milk protein
  • stunting
  • whey permeate

Publication forum classification

  • Publication forum level 1

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science
  • Nutrition and Dietetics

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