Abstract
The alternative enzymes of the respiratory chain, which are found in all the kingdoms of life, except for vertebrates, have received great interest for the treatment of disorders related to mitochondrial dysfunction. These enzymes have recently been used in cellular and animal models to understand and mitigate pathologies from mitochondrial diseases to Parkinson’s disease and cancer. The functional properties of these alternative enzymes have also helped to answer fundamental questions about the role of the respiratory chain in maintaining cellular and tissue metabolism. At the same time, the compatibility of these enzymes with mammalian metabolism has been widely characterized, and rejected on specific occasions. Although many questions remain to be answered regarding the metabolic impact of the alternative enzymes of the respiratory chain in humans, their potential as a therapeutic and research tool is starting to unravel.
| Original language | English |
|---|---|
| Title of host publication | Molecular Nutrition and Mitochondria |
| Subtitle of host publication | Metabolic Deficits, Whole-Diet Interventions, and Targeted Nutraceuticals |
| Editors | Sergej M. Ostojic |
| Publisher | Academic Press |
| Pages | 105-127 |
| Number of pages | 23 |
| ISBN (Electronic) | 978-0-323-90256-4 |
| ISBN (Print) | 978-0-323-98452-2 |
| DOIs | |
| Publication status | Published - 2022 |
| Publication type | A3 Book chapter |
Keywords
- alternative oxidase
- AOX
- Metabolism
- mitochondria
- mitochondrial disorder
- NDH2
- NDI1
- oxidative phosphorylation
- oxidative stress
- respiratory chain
Publication forum classification
- Publication forum level 2
ASJC Scopus subject areas
- General Biochemistry,Genetics and Molecular Biology
