Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

Daniel Bermejo-Velasco, Oommen P. Varghese, Oommen P. Oommen, Jöns Hilborn, Ganesh N. Nawale

    Research output: Contribution to journalArticleScientificpeer-review

    10 Citations (Scopus)

    Abstract

    We describe the fast reaction kinetics between 1,2-aminothiols and
    aldehydes. Under physiological conditions such a click-type reaction
    afforded a thiazolidine product that remains stable and did not
    require any catalyst. This type of bioorthogonal reaction offers
    enormous potential for the coupling of biomolecules in an efficient
    and biocompatible manner
    Original languageEnglish
    Pages (from-to)12507-12510
    Number of pages4
    JournalChemical Communications
    DOIs
    Publication statusPublished - 15 Oct 2018
    Publication typeA1 Journal article-refereed

    Publication forum classification

    • Publication forum level 2

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