Tidal breathing flow profiles during sleep in wheezing children measured by impedance pneumography

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For the first time, impedance pneumography (IP) enables a continuous analysis of the tidal breathing flow volume (TBFV), overnight. We studied how corticosteroid inhalation treatments, sleep stage, and time from sleep onset modify the nocturnal TBFV profiles of children. Seventy children, 1–5 years old and with recurrent wheezing, underwent three, full-night TBFVs recordings at home, using IP. The first recorded one week before ending a 3-months inhaled corticosteroids treatment, and remaining two, 2 and 4 weeks after treatment. TBFV profiles were grouped by hour from sleep onset and estimated sleep stage. Compared with on-medication, the off-medication profiles showed lower volume at exhalation peak flow, earlier interruption of expiration, and less convex middle expiration. The differences in the first two features were significant during non-rapid eye movement (NREM), and the differences in the third were more prominent during REM after 4 h of sleep. These combinations of TBFV features, sleep phase, and sleep time potentially indicate airflow limitation in young children.

Original languageEnglish
Article number103312
Pages (from-to)103312
JournalRespiratory Physiology and Neurobiology
Early online date2019
Publication statusPublished - 2020
Publication typeA1 Journal article-refereed


  • Impedance pneumography
  • Lung function
  • Tidal breathing
  • Wheezing children

Publication forum classification

  • Publication forum level 1


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