Towards Accurate and Model-Free QT Correction

Esa Räsänen, Ilya Potapov, Janne Solanpää, Katriina Aalto-Setälä

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Abstract

In the electrocardiogram (ECG), the QT interval is an important metric of risk for various adverse cardiovascular events and a key measure in cardiotoxicology. The main challenge in the interpretation of the QT measurement is its dependence on the heart rate, i.e., the RR intervals. To correct the QT interval for heart rate, a multitude of approximative methods have been developed, e.g., the power-law formulas of Bazett and Fridericia that are still in clinical use. However, these methods are known to under- or overcorrect the QT intervals, and none of the methods developed to date are universally applicable to different conditions. Here we present a QT correction method that is not based on models or empirical data, but directly utilizes information transfer between the RR and QT intervals during the measurement. The method dynamically adapts to a multitude of previous RR intervals and gives the QT correction as an output. We outline the essential principles of the method and provide a set of test results that demonstrate the stability of the corrected QT values in comparison with the conventional correction methods.
Original languageEnglish
Title of host publication2021 Computing in Cardiology (CinC)
Pages1-4
Number of pages4
ISBN (Electronic)978-1-6654-7916-5
DOIs
Publication statusPublished - 2021
Publication typeA4 Article in conference proceedings
EventComputing in cardiology - , Czech Republic
Duration: 13 Sept 202115 Sept 2021

Publication series

NameComputing in cardiology
ISSN (Electronic)2325-887X

Conference

ConferenceComputing in cardiology
Country/TerritoryCzech Republic
Period13/09/2115/09/21

Keywords

  • Heart rate
  • Measurement
  • Adaptation models
  • Computational modeling
  • Electrocardiography
  • Stability analysis
  • Data models

Publication forum classification

  • Publication forum level 1

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