TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Sanna Koskimäki; Sari Tojkander

doi:10.3390/s24216923

TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Sanna Koskimäki^*
, Sari Tojkander

^*Corresponding author for this work

Biosciences

Research output: Contribution to journal › Review Article › peer-review

2 Citations (Scopus)

5 Downloads (Pure)

Abstract

Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca²⁺-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels play such a wide role in various cellular and physiological functions, loss or impaired TRPV protein activity naturally contributes to many pathophysiological processes. This review concentrates on the known functions of TRPV4 sensor proteins and their potential as a therapeutic target.

Original language	English
Article number	6923
Journal	Sensors
Volume	24
Issue number	21
DOIs	https://doi.org/10.3390/s24216923
Publication status	Published - Nov 2024
Publication type	A2 Review article in a scientific journal

Keywords

mechanotransduction
sensors
therapeutic targeting
TRP channels
TRPV
TRPV4

Publication forum classification

Publication forum level 1

ASJC Scopus subject areas

Analytical Chemistry
Information Systems
Atomic and Molecular Physics, and Optics
Biochemistry
Instrumentation
Electrical and Electronic Engineering

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10.3390/s24216923Licence: CC BY

sensors-24-06923Final published version, 642 KBLicence: CC BY

https://urn.fi/URN:NBN:fi:tuni-2024112510455Licence: CC BY

Cite this

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title = "TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential",

abstract = "Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca2+-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels play such a wide role in various cellular and physiological functions, loss or impaired TRPV protein activity naturally contributes to many pathophysiological processes. This review concentrates on the known functions of TRPV4 sensor proteins and their potential as a therapeutic target.",

keywords = "mechanotransduction, sensors, therapeutic targeting, TRP channels, TRPV, TRPV4",

author = "Sanna Koskim{\"a}ki and Sari Tojkander",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = nov,

doi = "10.3390/s24216923",

language = "English",

volume = "24",

journal = "Sensors",

issn = "1424-8220",

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TY - JOUR

T1 - TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

AU - Koskimäki, Sanna

AU - Tojkander, Sari

PY - 2024/11

Y1 - 2024/11

N2 - Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca2+-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels play such a wide role in various cellular and physiological functions, loss or impaired TRPV protein activity naturally contributes to many pathophysiological processes. This review concentrates on the known functions of TRPV4 sensor proteins and their potential as a therapeutic target.

AB - Transient receptor potential vanilloid (TRPV) channel proteins belong to the superfamily of TRP proteins that form cationic channels in the animal cell membranes. These proteins have various subtype-specific functions, serving, for example, as sensors for pain, pressure, pH, and mechanical extracellular stimuli. The sensing of extracellular cues by TRPV4 triggers Ca2+-influx through the channel, subsequently coordinating numerous intracellular signaling cascades in a spatio-temporal manner. As TRPV channels play such a wide role in various cellular and physiological functions, loss or impaired TRPV protein activity naturally contributes to many pathophysiological processes. This review concentrates on the known functions of TRPV4 sensor proteins and their potential as a therapeutic target.

KW - mechanotransduction

KW - sensors

KW - therapeutic targeting

KW - TRP channels

KW - TRPV

KW - TRPV4

U2 - 10.3390/s24216923

DO - 10.3390/s24216923

M3 - Review Article

AN - SCOPUS:85208631704

SN - 1424-8220

VL - 24

JO - Sensors

JF - Sensors

IS - 21

M1 - 6923

ER -

TRPV4—A Multifunctional Cellular Sensor Protein with Therapeutic Potential

Abstract

Keywords

Publication forum classification

ASJC Scopus subject areas

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