Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer

Sherene Loi, Roberto Salgado, Sylvia Adams, Giancarlo Pruneri, Prudence A Francis, Magali Lacroix-Triki, Heikki Joensuu, Maria Vittoria Dieci, Sunil Badve, Sandra Demaria, Robert Gray, Elisabetta Munzone, Damien Drubay, Jerome Lemonnier, Christos Sotiriou, Pirkko Liisa Kellokumpu-Lehtinen, Andrea Vingiani, Kathryn Gray, Fabrice André, Carsten DenkertMartine Piccart, Elvire Roblin, Stefan Michiels

Research output: Contribution to journalArticleScientificpeer-review

Abstract

The importance of integrating biomarkers into the TNM staging has been emphasized in the 8th Edition of the American Joint Committee on Cancer (AJCC) Staging system. In a pooled analysis of 2148 TNBC-patients in the adjuvant setting, TILs are found to strongly up and downstage traditional pathological-staging in the Pathological and Clinical Prognostic Stage Groups from the AJJC 8th edition Cancer Staging System. This suggest that clinical and research studies on TNBC should take TILs into account in addition to stage, as for example patients with stage II TNBC and high TILs have a better outcome than patients with stage I and low TILs.

Original languageEnglish
Article number3
JournalNPJ breast cancer
Volume8
DOIs
Publication statusPublished - 11 Jan 2022
Publication typeA1 Journal article-refereed

Publication forum classification

  • Publication forum level 1

Fingerprint

Dive into the research topics of 'Tumor infiltrating lymphocyte stratification of prognostic staging of early-stage triple negative breast cancer'. Together they form a unique fingerprint.

Cite this