Two cations, two mechanisms: Interactions of sodium and calcium with zwitterionic lipid membranes

Matti Javanainen, Adéla Melcrová, Aniket Magarkar, Piotr Jurkiewicz, Martin Hof, Pavel Jungwirth, Hector Martinez-Seara

    Research output: Contribution to journalArticleScientificpeer-review

    23 Citations (Scopus)
    5 Downloads (Pure)


    Adsorption of metal cations onto a cellular membrane changes its properties, such as interactions with charged moieties or the propensity for membrane fusion. It is, however, unclear whether cells can regulate ion adsorption and the related functions via locally adjusting their membrane composition. We employed fluorescence techniques and computer simulations to determine how the presence of cholesterol - a key molecule inducing membrane heterogeneity - affects the adsorption of sodium and calcium onto zwitterionic phosphatidylcholine bilayers. We found that the transient adsorption of sodium is dependent on the number of phosphatidylcholine head groups, while the strong surface binding of calcium is determined by the available surface area of the membrane. Cholesterol thus does not affect sodium adsorption and only plays an indirect role in modulating the adsorption of calcium by increasing the total surface area of the membrane. These observations also indicate how lateral lipid heterogeneity can regulate various ion-induced processes including adsorption of peripheral proteins, nanoparticles, and other molecules onto membranes.

    Original languageEnglish
    Pages (from-to)5380-5383
    Number of pages4
    JournalChemical Communications
    Issue number39
    Publication statusPublished - 2017
    Publication typeA1 Journal article-refereed

    Publication forum classification

    • Publication forum level 2

    ASJC Scopus subject areas

    • Catalysis
    • Electronic, Optical and Magnetic Materials
    • Ceramics and Composites
    • Chemistry(all)
    • Surfaces, Coatings and Films
    • Metals and Alloys
    • Materials Chemistry


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