TY - JOUR
T1 - What more can be done? Prioritizing the most promising antenatal interventions to improve birth weight
AU - The LBW prevention prioritization working group
AU - Koivu, Annariina M.
AU - Haapaniemi, Tiia
AU - Askari, Sufia
AU - Bhandari, Nita
AU - Black, Robert E.
AU - Chico, R. Matthew
AU - Dewey, Kathryn G.
AU - Duggan, Christopher P.
AU - Klein, Nigel
AU - Kumar, Somesh
AU - Lawn, Joy E.
AU - Manji, Karim
AU - Näsänen-Gilmore, Pieta K.
AU - Salasibew, Mihretab
AU - Semrau, Katherine E.A.
AU - Ashorn, Ulla
AU - Ashorn, Per
N1 - Funding Information:
This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children’s Investment Fund Foundation.
Funding Information:
The study was funded by the Children's Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973. Dr. Duggan was supported in part by the National Institutes of Health (K24DK104676 and 2P30 DK040561).
Funding Information:
The study was funded by the Children’s Investment Fund Foundation (CIFF) , Grant Reference Number 1808-02973 . Dr. Duggan was supported in part by the National Institutes of Health ( K24DK104676 and 2P30 DK040561 ).
Publisher Copyright:
© 2023 American Society for Nutrition
PY - 2023/6
Y1 - 2023/6
N2 - Background: Low birth weight (LBW) is associated with neonatal mortality and sequelae of lifelong health problems; prioritizing the most promising antenatal interventions may guide resource allocation and improve health outcomes. Objective: We sought to identify the most promising interventions that are not yet included in the policy recommendations of the World Health Organization (WHO) but could complement antenatal care and reduce the prevalence of LBW and related adverse birth outcomes in low- and middle-income settings. Methods: We utilized an adapted Child Health and Nutrition Research Initiative (CHNRI) prioritization method. Results: In addition to procedures already recommended by WHO for the prevention of LBW, we identified six promising antenatal interventions that are not currently recommended by WHO with an indication for LBW prevention, namely: (1) provision of multiple micronutrients; (2) low-dose aspirin; (3) high-dose calcium; (4) prophylactic cervical cerclage; (5) psychosocial support for smoking cessation; and (6) other psychosocial support for targeted populations and settings. We also identified seven interventions for further implementation research and six interventions for efficacy research. Conclusion: These promising interventions, coupled with increasing coverage of currently recommended antenatal care, could accelerate progress toward the global target of a 30% reduction in the number of LBW infants born in 2025 compared to 2006-10.
AB - Background: Low birth weight (LBW) is associated with neonatal mortality and sequelae of lifelong health problems; prioritizing the most promising antenatal interventions may guide resource allocation and improve health outcomes. Objective: We sought to identify the most promising interventions that are not yet included in the policy recommendations of the World Health Organization (WHO) but could complement antenatal care and reduce the prevalence of LBW and related adverse birth outcomes in low- and middle-income settings. Methods: We utilized an adapted Child Health and Nutrition Research Initiative (CHNRI) prioritization method. Results: In addition to procedures already recommended by WHO for the prevention of LBW, we identified six promising antenatal interventions that are not currently recommended by WHO with an indication for LBW prevention, namely: (1) provision of multiple micronutrients; (2) low-dose aspirin; (3) high-dose calcium; (4) prophylactic cervical cerclage; (5) psychosocial support for smoking cessation; and (6) other psychosocial support for targeted populations and settings. We also identified seven interventions for further implementation research and six interventions for efficacy research. Conclusion: These promising interventions, coupled with increasing coverage of currently recommended antenatal care, could accelerate progress toward the global target of a 30% reduction in the number of LBW infants born in 2025 compared to 2006-10.
KW - Antenatal care (ANC)
KW - Child Health and Nutrition Research Initiative (CHNRI) method
KW - Low birth weight (LBW)
KW - Low- and middle-income countries (LMICs)
KW - Preterm birth (PTB)
KW - Priority-setting
U2 - 10.1016/j.ajcnut.2022.10.022
DO - 10.1016/j.ajcnut.2022.10.022
M3 - Article
C2 - 37331758
AN - SCOPUS:85161982477
SN - 0002-9165
VL - 117
SP - S107-S117
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
ER -
