TY - JOUR
T1 - A Higher Mean Heart Radiation Dose Induces Higher Frequency of Multiple Cardiac Changes
AU - Tuohinen, Suvi Sirkku
AU - Aula, Hanna
AU - Skyttä, Tanja
AU - Huhtala, Heini
AU - Keski-Pukkila, Konsta
AU - Nikus, Kjell
AU - Virtanen, Vesa
AU - Kellokumpu-Lehtinen, Pirkko Liisa
AU - Raatikainen, Pekka
N1 - Publisher Copyright:
Copyright © 2022 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.
PY - 2022/5
Y1 - 2022/5
N2 - BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.
AB - BACKGROUND/AIM: Radiotherapy (RT) induces late changes in all cardiac structures. Most studies of early changes focus on individual parameters. PATIENTS AND METHODS: Data from eighty early-stage breast cancer patients at baseline, post-RT and three-year follow-up visit were assessed prospectively. Changes in ten cardiac parameters were collected including electrocardiogram (ECG), echocardiography, and biomarkers. A percentage of abnormal changes was calculated. RESULTS: The mean heart radiation dose (Dmean) was independently associated with the increased incidence of changes post-RT (β=0.403, p<0.001) and at the three-year follow-up (β=0.353, p=0.001). Each 1-Gray increase in Dmean increased the cardiac changes by 3.7% (95%CI=1.9-5.6%) after RT and 3.1% (95%CI=1.3, 4.9%) at the three-year follow-up. CONCLUSION: A higher cardiac radiation dose was independently associated with a higher incidence of changes in cardiac parameters. Multiparameter changes imply that the early phase after RT is already characterized by several overlapping cardiac changes.
KW - Breast cancer
KW - cardiac biomarkers
KW - ECG
KW - echocardiography
KW - radiotherapy
U2 - 10.21873/anticanres.15730
DO - 10.21873/anticanres.15730
M3 - Article
C2 - 35489742
AN - SCOPUS:85129143665
SN - 1791-7530
VL - 42
SP - 2519
EP - 2529
JO - Anticancer research
JF - Anticancer research
IS - 5
ER -