A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight

Patricia J. Hunter; Yvonne Muthiani; Pieta K. Näsänen-Gilmore; Annariina M. Koivu; Pia Pörtfors; Kalpana Bastola; Raija Vimpeli; Juho Luoma; Ulla Ashorn; Per Ashorn

doi:10.1016/j.ajcnut.2023.01.024

A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight

Patricia J. Hunter, Yvonne Muthiani, Pieta K. Näsänen-Gilmore, Annariina M. Koivu, Pia Pörtfors, Kalpana Bastola, Raija Vimpeli, Juho Luoma, Ulla Ashorn, Per Ashorn

LAST, Lastentaudit

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

10 Sitaatiot (Scopus)

Abstrakti

Background: Poor nutrition during pregnancy can lead to adverse birth outcomes including low birth weight (LBW). Objective: This modular systematic review aimed to provide evidence for the effects of seven antenatal nutritional interventions on the risks of LBW, preterm birth (PTB), small-for-gestational-age (SGA) and stillbirth (SB). Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and CINAHL Complete between April and June 2020, with a further update in September 2022 (Embase only). We included randomized controlled trials (RCTs) and reviews of RCTs to estimate the effect sizes of the selected interventions on the four birth outcomes. Results: Evidence suggests that balanced protein and energy (BPE) supplementation for pregnant women with undernutrition can reduce the risk of LBW, SGA and SB. Evidence from low and lower middle-income countries (MIC) suggests that multiple micronutrient (MMN) supplementation can reduce the risk of LBW and SGA in comparison with iron or iron and folic acid supplementation and lipid-based nutrient supplements (LNS) with any quantity of energy can reduce the risk of LBW in comparison with MMN supplementation. Evidence from high and upper MIC suggests that supplementation with omega-3 fatty acids (O3FA) can reduce the risk and supplementation with high-dose calcium might possibly reduce the risk of LBW and PTB. Antenatal dietary education programs might possibly reduce the risk of LBW in comparison with standard-of-care. No RCTs were identified for monitoring weight gain followed by interventions to support weight gain in women who are underweight. Conclusions: Provision of BPE, MMN and LNS to pregnant women in populations with undernutrition can reduce the risk of LBW and related outcomes. The benefits of O3FA and calcium supplementation to this population require further investigation. Targeting interventions to pregnant women who are not gaining weight has not been tested with RCTs.

Alkuperäiskieli	Englanti
Sivut	S134-S147
Sivumäärä	14
Julkaisu	American Journal of Clinical Nutrition
Vuosikerta	117
Numero	Supplement 2
DOI - pysyväislinkit	https://doi.org/10.1016/j.ajcnut.2023.01.024
Tila	Julkaistu - kesäk. 2023
OKM-julkaisutyyppi	A2 Katsausartikkeli tieteellisessä aikakauslehdessä

Rahoitus

The study was funded by The Children’s Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973 . The study was funded by The Children's Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973. This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children's Investment Fund Foundation.

Julkaisufoorumi-taso

Jufo-taso 3

!!ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

Pääsy asiakirjaan

10.1016/j.ajcnut.2023.01.024

https://discovery.ucl.ac.uk/id/eprint/10168081Lisenssi: CC BY-NC-ND

Siteeraa tätä

Hunter, P. J., Muthiani, Y., Näsänen-Gilmore, P. K., Koivu, A. M., Pörtfors, P., Bastola, K., Vimpeli, R., Luoma, J., Ashorn, U., & Ashorn, P. (2023). A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight. American Journal of Clinical Nutrition, 117(Supplement 2), S134-S147. https://doi.org/10.1016/j.ajcnut.2023.01.024

@article{9fed651f98f441eda360d7b1d26f309c,

title = "A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight",

abstract = "Background: Poor nutrition during pregnancy can lead to adverse birth outcomes including low birth weight (LBW). Objective: This modular systematic review aimed to provide evidence for the effects of seven antenatal nutritional interventions on the risks of LBW, preterm birth (PTB), small-for-gestational-age (SGA) and stillbirth (SB). Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and CINAHL Complete between April and June 2020, with a further update in September 2022 (Embase only). We included randomized controlled trials (RCTs) and reviews of RCTs to estimate the effect sizes of the selected interventions on the four birth outcomes. Results: Evidence suggests that balanced protein and energy (BPE) supplementation for pregnant women with undernutrition can reduce the risk of LBW, SGA and SB. Evidence from low and lower middle-income countries (MIC) suggests that multiple micronutrient (MMN) supplementation can reduce the risk of LBW and SGA in comparison with iron or iron and folic acid supplementation and lipid-based nutrient supplements (LNS) with any quantity of energy can reduce the risk of LBW in comparison with MMN supplementation. Evidence from high and upper MIC suggests that supplementation with omega-3 fatty acids (O3FA) can reduce the risk and supplementation with high-dose calcium might possibly reduce the risk of LBW and PTB. Antenatal dietary education programs might possibly reduce the risk of LBW in comparison with standard-of-care. No RCTs were identified for monitoring weight gain followed by interventions to support weight gain in women who are underweight. Conclusions: Provision of BPE, MMN and LNS to pregnant women in populations with undernutrition can reduce the risk of LBW and related outcomes. The benefits of O3FA and calcium supplementation to this population require further investigation. Targeting interventions to pregnant women who are not gaining weight has not been tested with RCTs.",

keywords = "antenatal care, low birth weight, nutrition, pregnancy, preterm birth, small-for-gestational-age, stillbirth, undernutrition",

author = "Hunter, {Patricia J.} and Yvonne Muthiani and N{\"a}s{\"a}nen-Gilmore, {Pieta K.} and Koivu, {Annariina M.} and Pia P{\"o}rtfors and Kalpana Bastola and Raija Vimpeli and Juho Luoma and Ulla Ashorn and Per Ashorn",

note = "Funding Information: The study was funded by The Children{\textquoteright}s Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973 . Funding Information: The study was funded by The Children's Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973. Funding Information: This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children's Investment Fund Foundation. Publisher Copyright: {\textcopyright} 2023 American Society for Nutrition",

year = "2023",

month = jun,

doi = "10.1016/j.ajcnut.2023.01.024",

language = "English",

volume = "117",

pages = "S134--S147",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "Supplement 2",

}

Hunter, PJ, Muthiani, Y , Näsänen-Gilmore, PK, Koivu, AM, Pörtfors, P, Bastola, K, Vimpeli, R, Luoma, J , Ashorn, U & Ashorn, P 2023, 'A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight', American Journal of Clinical Nutrition, Vuosikerta 117, Nro Supplement 2, Sivut S134-S147. https://doi.org/10.1016/j.ajcnut.2023.01.024

A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight. / Hunter, Patricia J.; Muthiani, Yvonne ; Näsänen-Gilmore, Pieta K. et al.
julkaisussa: American Journal of Clinical Nutrition, Vuosikerta 117, Nro Supplement 2, 06.2023, s. S134-S147.

Tutkimustuotos: Katsausartikkeli › vertaisarvioitu

TY - JOUR

T1 - A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight

AU - Hunter, Patricia J.

AU - Muthiani, Yvonne

AU - Näsänen-Gilmore, Pieta K.

AU - Koivu, Annariina M.

AU - Pörtfors, Pia

AU - Bastola, Kalpana

AU - Vimpeli, Raija

AU - Luoma, Juho

AU - Ashorn, Ulla

AU - Ashorn, Per

N1 - Funding Information: The study was funded by The Children’s Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973 . Funding Information: The study was funded by The Children's Investment Fund Foundation (CIFF), Grant Reference Number 1808-02973. Funding Information: This article is published as part of a supplement sponsored by Tampere University, Faculty of Medicine and Health Technology with grant support from the Children's Investment Fund Foundation. Publisher Copyright: © 2023 American Society for Nutrition

PY - 2023/6

Y1 - 2023/6

N2 - Background: Poor nutrition during pregnancy can lead to adverse birth outcomes including low birth weight (LBW). Objective: This modular systematic review aimed to provide evidence for the effects of seven antenatal nutritional interventions on the risks of LBW, preterm birth (PTB), small-for-gestational-age (SGA) and stillbirth (SB). Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and CINAHL Complete between April and June 2020, with a further update in September 2022 (Embase only). We included randomized controlled trials (RCTs) and reviews of RCTs to estimate the effect sizes of the selected interventions on the four birth outcomes. Results: Evidence suggests that balanced protein and energy (BPE) supplementation for pregnant women with undernutrition can reduce the risk of LBW, SGA and SB. Evidence from low and lower middle-income countries (MIC) suggests that multiple micronutrient (MMN) supplementation can reduce the risk of LBW and SGA in comparison with iron or iron and folic acid supplementation and lipid-based nutrient supplements (LNS) with any quantity of energy can reduce the risk of LBW in comparison with MMN supplementation. Evidence from high and upper MIC suggests that supplementation with omega-3 fatty acids (O3FA) can reduce the risk and supplementation with high-dose calcium might possibly reduce the risk of LBW and PTB. Antenatal dietary education programs might possibly reduce the risk of LBW in comparison with standard-of-care. No RCTs were identified for monitoring weight gain followed by interventions to support weight gain in women who are underweight. Conclusions: Provision of BPE, MMN and LNS to pregnant women in populations with undernutrition can reduce the risk of LBW and related outcomes. The benefits of O3FA and calcium supplementation to this population require further investigation. Targeting interventions to pregnant women who are not gaining weight has not been tested with RCTs.

AB - Background: Poor nutrition during pregnancy can lead to adverse birth outcomes including low birth weight (LBW). Objective: This modular systematic review aimed to provide evidence for the effects of seven antenatal nutritional interventions on the risks of LBW, preterm birth (PTB), small-for-gestational-age (SGA) and stillbirth (SB). Methods: We searched MEDLINE, Embase, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and CINAHL Complete between April and June 2020, with a further update in September 2022 (Embase only). We included randomized controlled trials (RCTs) and reviews of RCTs to estimate the effect sizes of the selected interventions on the four birth outcomes. Results: Evidence suggests that balanced protein and energy (BPE) supplementation for pregnant women with undernutrition can reduce the risk of LBW, SGA and SB. Evidence from low and lower middle-income countries (MIC) suggests that multiple micronutrient (MMN) supplementation can reduce the risk of LBW and SGA in comparison with iron or iron and folic acid supplementation and lipid-based nutrient supplements (LNS) with any quantity of energy can reduce the risk of LBW in comparison with MMN supplementation. Evidence from high and upper MIC suggests that supplementation with omega-3 fatty acids (O3FA) can reduce the risk and supplementation with high-dose calcium might possibly reduce the risk of LBW and PTB. Antenatal dietary education programs might possibly reduce the risk of LBW in comparison with standard-of-care. No RCTs were identified for monitoring weight gain followed by interventions to support weight gain in women who are underweight. Conclusions: Provision of BPE, MMN and LNS to pregnant women in populations with undernutrition can reduce the risk of LBW and related outcomes. The benefits of O3FA and calcium supplementation to this population require further investigation. Targeting interventions to pregnant women who are not gaining weight has not been tested with RCTs.

KW - antenatal care

KW - low birth weight

KW - nutrition

KW - pregnancy

KW - preterm birth

KW - small-for-gestational-age

KW - stillbirth

KW - undernutrition

U2 - 10.1016/j.ajcnut.2023.01.024

DO - 10.1016/j.ajcnut.2023.01.024

M3 - Review Article

AN - SCOPUS:85161988132

SN - 0002-9165

VL - 117

SP - S134-S147

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - Supplement 2

ER -

A modular systematic review of antenatal interventions to address undernutrition during pregnancy in the prevention of low birth weight

Abstrakti

Rahoitus

Julkaisufoorumi-taso

!!ASJC Scopus subject areas

YK:n kestävän kehityksen tavoitteet

Pääsy asiakirjaan

Sormenjälki

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