A retrospective study of accuracy and usefulness of electrophysiological exercise tests

Vesa Periviita, Manu Jokela, Johanna Palmio, Bjarne Udd

Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

21 Lataukset (Pure)

Abstrakti

OBJECTIVES: This study aimed to determine the usefulness of electrophysiological exercise tests. The significance of slightly abnormal exercise tests was also examined.

METHODS: We identified all the patients who had undergone exercise testing between February 2007 to June 2022 in Tampere University Hospital, Finland. Their medical records after diagnostic workup and exercise test reports were reviewed. A binary logistic regression was performed to evaluate the association between positive test result in short exercise test, long exercise test, or short exercise test with cooling and genetically confirmed skeletal muscle channelopathy or myotonic disorder.

RESULTS: We identified 256 patients. 27 patients were diagnosed with nondystrophic myotonia, periodic paralysis, myotonic dystrophy type 1, myotonic dystrophy type 2, or other specified myopathy. 14 patients were suspected to have a skeletal muscle channelopathy, but pathogenic variants could not be identified. The remaining 215 patients were diagnosed with other conditions than skeletal muscle channelopathy or myotonic disorder. The combined sensitivity of exercise tests was 59.3% and specificity 99.1%. Abnormal exercise test result was associated with increased risk of skeletal muscle channelopathy or myotonic disorder (OR 164.3, 95% CI 28.3-954.6, p < 0.001).

CONCLUSIONS: Electrophysiological exercise test is not optimal to exclude skeletal muscle channelopathy. It may be useful if a skeletal muscle channelopathy is suspected and genetic testing is negative or indeterminate and further evidence is required. Slightly abnormal exercise test results are possible in various conditions and result from different aetiologies. There is a demand for neurophysiological studies with higher sensitivity to detect skeletal muscle channelopathies.

AlkuperäiskieliEnglanti
Sivut1802-1812
Sivumäärä11
JulkaisuJOURNAL OF NEUROLOGY
Vuosikerta271
Numero4
Varhainen verkossa julkaisun päivämääräjouluk. 2023
DOI - pysyväislinkit
TilaJulkaistu - huhtik. 2024
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 2

!!ASJC Scopus subject areas

  • Clinical Neurology

Sormenjälki

Sukella tutkimusaiheisiin 'A retrospective study of accuracy and usefulness of electrophysiological exercise tests'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä