A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management

Nadine G. Andersson; Mathias Rathe; Ingolf Mølle; Kirsten Brunswig Jarvis; Marianne Hoffmann; Anu Huurre; Joel Joelsson; Birgitte Klug Albertsen; Olli Lohi; Satu Långström; Ulrik Overgaard; Sonata Saulyte Trakymiene; Kaisa Vepsäläinen; Hartmut Vogt; Susanna Ranta

doi:10.1111/bjh.18397

A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management

Nadine G. Andersson, Mathias Rathe, Ingolf Mølle, Kirsten Brunswig Jarvis, Marianne Hoffmann, Anu Huurre, Joel Joelsson, Birgitte Klug Albertsen, Olli Lohi, Satu Långström, Ulrik Overgaard, Sonata Saulyte Trakymiene, Kaisa Vepsäläinen, Hartmut Vogt, Susanna Ranta

Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

5 Lataukset (Pure)

Abstrakti

Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

Alkuperäiskieli	Englanti
Sivumäärä	5
Julkaisu	British Journal of Haematology
Vuosikerta	199
Numero	1
DOI - pysyväislinkit	https://doi.org/10.1111/bjh.18397
Tila	Julkaistu - 2022
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 2

!!ASJC Scopus subject areas

Hematology

YK:n kestävän kehityksen tavoitteet

Tämä tuotos edistää seuraavia kestävän kehityksen tavoitteita:

Pääsy asiakirjaan

10.1111/bjh.18397Lisenssi: CC BY-NC-ND

Br J Haematol - 2022 - Andersson - A survey on thromboprophylaxis and coagulation assessment in children and young adultsFinal published version, 361 KBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202208186516Lisenssi: CC BY-NC-ND

Sormenjälki

Sukella tutkimusaiheisiin 'A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management'. Ne muodostavat yhdessä ainutlaatuisen sormenjäljen.

Siteeraa tätä

Andersson, N. G., Rathe, M., Mølle, I., Jarvis, K. B., Hoffmann, M., Huurre, A., Joelsson, J., Albertsen, B. K., Lohi, O., Långström, S., Overgaard, U., Saulyte Trakymiene, S., Vepsäläinen, K., Vogt, H., & Ranta, S. (2022). A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management. British Journal of Haematology, 199(1). https://doi.org/10.1111/bjh.18397

@article{0e49734a48134d57a15ffc4c6edef822,

title = "A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management",

abstract = "Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.",

keywords = "ALL, antithrombin, childhood leukaemia, paediatric haemostasis, paediatric thrombosis, thrombosis",

author = "Andersson, {Nadine G.} and Mathias Rathe and Ingolf M{\o}lle and Jarvis, {Kirsten Brunswig} and Marianne Hoffmann and Anu Huurre and Joel Joelsson and Albertsen, {Birgitte Klug} and Olli Lohi and Satu L{\aa}ngstr{\"o}m and Ulrik Overgaard and {Saulyte Trakymiene}, Sonata and Kaisa Veps{\"a}l{\"a}inen and Hartmut Vogt and Susanna Ranta",

note = "Publisher Copyright: {\textcopyright} 2022 The Authors. British Journal of Haematology published by British Society for Haematology and John Wiley & Sons Ltd.",

year = "2022",

doi = "10.1111/bjh.18397",

language = "English",

volume = "199",

journal = "British Journal of Haematology",

issn = "0007-1048",

publisher = "Wiley",

number = "1",

}

Andersson, NG, Rathe, M, Mølle, I, Jarvis, KB, Hoffmann, M, Huurre, A, Joelsson, J, Albertsen, BK, Lohi, O, Långström, S, Overgaard, U, Saulyte Trakymiene, S, Vepsäläinen, K, Vogt, H & Ranta, S 2022, 'A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries: Different practices of assessment and management', British Journal of Haematology, Vuosikerta 199, Nro 1. https://doi.org/10.1111/bjh.18397

A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries : Different practices of assessment and management. / Andersson, Nadine G.; Rathe, Mathias; Mølle, Ingolf et al.

julkaisussa: British Journal of Haematology, Vuosikerta 199, Nro 1, 2022.

Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

TY - JOUR

T1 - A survey on thromboprophylaxis and coagulation assessment in children and young adults with acute lymphoblastic leukaemia (ALL) in the Nordic and Baltic countries

T2 - Different practices of assessment and management

AU - Andersson, Nadine G.

AU - Rathe, Mathias

AU - Mølle, Ingolf

AU - Jarvis, Kirsten Brunswig

AU - Hoffmann, Marianne

AU - Huurre, Anu

AU - Joelsson, Joel

AU - Albertsen, Birgitte Klug

AU - Lohi, Olli

AU - Långström, Satu

AU - Overgaard, Ulrik

AU - Saulyte Trakymiene, Sonata

AU - Vepsäläinen, Kaisa

AU - Vogt, Hartmut

AU - Ranta, Susanna

PY - 2022

Y1 - 2022

N2 - Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

AB - Patients undergoing treatment for acute lymphoblastic leukaemia (ALL) are at risk of coagulopathy, especially thromboembolism. We conducted a survey on practices in the assessment and management of coagulopathy during the new ALLTogether protocol in 29 (17 paediatric, 12 adult) Nordic and Baltic cancer centres. While 92% of adult centres used thromboprophylaxis with low-molecular-weight heparin, no paediatric centre did. Almost all providers performed baseline coagulation studies, but only 59% continued the assessment. Fibrinogen replacement was conducted in 59%, and antithrombin replacement in 28% of the centres. The survey highlights the need for guidelines in the management of coagulopathy during ALL therapy.

KW - ALL

KW - antithrombin

KW - childhood leukaemia

KW - paediatric haemostasis

KW - paediatric thrombosis

KW - thrombosis

U2 - 10.1111/bjh.18397

DO - 10.1111/bjh.18397

M3 - Article

AN - SCOPUS:85135264603

SN - 0007-1048

VL - 199

JO - British Journal of Haematology

JF - British Journal of Haematology

IS - 1

ER -