Accumulation of Lewy-Related Pathology Starts in Middle Age: The Tampere Sudden Death Study

Tutkimustuotos: ArtikkeliScientificvertaisarvioitu

7 Lataukset (Pure)

Abstrakti

When effective treatments against neurodegenerative diseases become a reality, it will be important to know the age these pathologies begin to develop. We investigated alpha-synuclein pathology in brain tissue of the Tampere Sudden Death Study—unselected forensic autopsies on individuals living outside hospital institutions in Finland. Of 562 (16–95 years) participants, 42 were positive for Lewy-related pathology (LRP). The youngest LRP case was aged 54 years, and the frequency of LRP in individuals aged ≥50 years was 9%. This forensic autopsy study indicates LRP starts already in middle age and is more common than expected in the ≥50 years-of-age non-hospitalized population. ANN NEUROL 2024.

AlkuperäiskieliEnglanti
Sivumäärä6
JulkaisuANNALS OF NEUROLOGY
DOI - pysyväislinkit
TilaE-pub ahead of print - 2024
OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

  • Jufo-taso 3

!!ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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