Altered polyamine profiles in colorectal cancer

MK Venäläinen, AN Roine, MR Häkkinen, JJ Vepsäläinen, Pekka S. Kumpulainen, MS Kiviniemi, T Lehtimäki, N Oksala, TK Rantanen

Tutkimustuotos: ArticleScientificvertaisarvioitu

7 Sitaatiot (Scopus)

Abstrakti

Background: The declining mortality rate of patients with colorectal cancer (CRC) can be explained, at least partially, with early diagnosis. Simple diagnostic methods are needed to achieve a maximal patient participation rate in screening. Materials and Methods: Liquid chromatography electrospray tandem mass spectrometry (LC-MS/MS) was used to determine urinary polyamine (PA) profiles. In a prospective setting, 116 patients were included in the study: 57 with CRC, 13 with inflammatory bowel disease (IBD), 12 with adenoma, and 34 controls. Results: N1,N12-diacetylspermine (DiAcSPM) level was significantly higher in patients with CRC than controls (sensitivity=78.0%, specificity=70.6%: p=0.00049). The level of diacetylated cadaverine (p=0.0068) was lower and that of diacetylated putrescine (p=0.0078) was higher in patients with CRC than in those with IBD. Cadaverine (p=0.00010) and spermine (p=0.042) levels were lower and that of DiAcSPM (p=0.018) higher in patients with CRC than in those with adenoma. Conclusion: The simultaneous determination of urinary PAs by means of LC-MS/MS can be used to discriminate CRC from controls and patients with benign colorectal diseases.

AlkuperäiskieliEnglanti
Sivut3601-3607
Sivumäärä7
JulkaisuAnticancer research
Vuosikerta38
Numero6
DOI - pysyväislinkit
TilaJulkaistu - 2018
OKM-julkaisutyyppiA1 Alkuperäisartikkeli

Tutkimusalat

  • Colorectal cancer
  • Diagnostic methods
  • Inflammatory bowel disease
  • Polyamines

Julkaisufoorumi-taso

  • Jufo-taso 1

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