Antibody Responses to Transglutaminase 3 in Dermatitis Herpetiformis: Lessons from Celiac Disease

Tutkimustuotos: Katsausartikkelivertaisarvioitu

21 Lataukset (Pure)

Abstrakti

Dermatitis herpetiformis (DH) is the skin manifestation of celiac disease, presenting with a blistering rash typically on the knees, elbows, buttocks and scalp. In both DH and celiac disease, exposure to dietary gluten triggers a cascade of events resulting in the production of autoantibodies against the transglutaminase (TG) enzyme, mainly TG2 but often also TG3. The latter is considered to be the primary autoantigen in DH. The dynamics of the development of the TG2-targeted autoimmune response have been studied in depth in celiac disease, but the immunological process underlying DH pathophysiology is incompletely understood. Part of this process is the occurrence of granular deposits of IgA and TG3 in the perilesional skin. While this serves as the primary diagnostic finding in DH, the role of these immunocomplexes in the pathogenesis is unknown. Intriguingly, even though gluten-intolerance likely develops initially in a similar manner in both DH and celiac disease, after the onset of the disease, its manifestations differ widely.

AlkuperäiskieliEnglanti
Artikkeli2910
Sivumäärä11
JulkaisuInternational Journal of Molecular Sciences
Vuosikerta23
Numero6
DOI - pysyväislinkit
TilaJulkaistu - maalisk. 2022
OKM-julkaisutyyppiA2 Katsausartikkeli tieteellisessä aikakauslehdessä

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