TY - JOUR
T1 - Approaches for corneal endothelium regenerative medicine
AU - Català, Pere
AU - Thuret, Gilles
AU - Skottman, Heli
AU - Mehta, Jodhbir S.
AU - Parekh, Mohit
AU - Ní Dhubhghaill, Sorcha
AU - Collin, Rob W.J.
AU - Nuijts, Rudy M.M.A.
AU - Ferrari, Stefano
AU - LaPointe, Vanessa L.S.
AU - Dickman, Mor M.
N1 - Funding Information:
P.C., R.M.M.N, V.L.S.L, and M.M.D. were funded to perform this work by Chemelot InSciTe under the EyeSciTe consortium.
PY - 2022
Y1 - 2022
N2 - The state of the art therapy for treating corneal endothelial disease is transplantation. Advances in the reproducibility and accessibility of surgical techniques are increasing the number of corneal transplants, thereby causing a global deficit of donor corneas and leaving 12.7 million patients with addressable visual impairment. Approaches to regenerate the corneal endothelium offer a solution to the current tissue scarcity and a treatment to those in need. Methods for generating corneal endothelial cells into numbers that could address the current tissue shortage and the possible strategies used to deliver them have now become a therapeutic reality with clinical trials taking place in Japan, Singapore and Mexico. Nevertheless, there is still a long way before such therapies are approved by regulatory bodies and become clinical practice. Moreover, acellular corneal endothelial graft equivalents and certain drugs could provide a treatment option for specific disease conditions without the need of donor tissue or cells. Finally, with the emergence of gene modulation therapies to treat corneal endothelial disease, it would be possible to treat presymptomatic patients or those presenting early symptoms, drastically reducing the need for donor tissue. It is necessary to understand the most recent developments in this rapidly evolving field to know which conditions could be treated with which approach. This article provides an overview of the current and developing regenerative medicine therapies to treat corneal endothelial disease and provides the necessary guidance and understanding towards the treatment of corneal endothelial disease.
AB - The state of the art therapy for treating corneal endothelial disease is transplantation. Advances in the reproducibility and accessibility of surgical techniques are increasing the number of corneal transplants, thereby causing a global deficit of donor corneas and leaving 12.7 million patients with addressable visual impairment. Approaches to regenerate the corneal endothelium offer a solution to the current tissue scarcity and a treatment to those in need. Methods for generating corneal endothelial cells into numbers that could address the current tissue shortage and the possible strategies used to deliver them have now become a therapeutic reality with clinical trials taking place in Japan, Singapore and Mexico. Nevertheless, there is still a long way before such therapies are approved by regulatory bodies and become clinical practice. Moreover, acellular corneal endothelial graft equivalents and certain drugs could provide a treatment option for specific disease conditions without the need of donor tissue or cells. Finally, with the emergence of gene modulation therapies to treat corneal endothelial disease, it would be possible to treat presymptomatic patients or those presenting early symptoms, drastically reducing the need for donor tissue. It is necessary to understand the most recent developments in this rapidly evolving field to know which conditions could be treated with which approach. This article provides an overview of the current and developing regenerative medicine therapies to treat corneal endothelial disease and provides the necessary guidance and understanding towards the treatment of corneal endothelial disease.
KW - Cell therapy
KW - Corneal endothelial disease
KW - Gene therapy
KW - Pharmacological modulation
KW - Regenerative medicine
KW - Tissue engineering
U2 - 10.1016/j.preteyeres.2021.100987
DO - 10.1016/j.preteyeres.2021.100987
M3 - Review Article
AN - SCOPUS:85110429422
SN - 1350-9462
VL - 87
JO - Progress in Retinal and Eye Research
JF - Progress in Retinal and Eye Research
M1 - 100987
ER -