Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis

Li Sheng Chen; Jean Ching Yuan Fann; Sherry Yueh Hsia Chiu; Amy Ming Fang Yen; Tiina Wahlfors; Teuvo L. Tammela; Hsiu Hsi Chen; Anssi Auvinen; Johanna Schleutker

doi:10.1371/journal.pone.0089508

Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis

Li Sheng Chen, Jean Ching Yuan Fann, Sherry Yueh Hsia Chiu, Amy Ming Fang Yen, Tiina Wahlfors, Teuvo L. Tammela, Hsiu Hsi Chen, Anssi Auvinen, Johanna Schleutker

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

8 Sitaatiot (Scopus)

Abstrakti

Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228 cases in 75 families, to evaluate the respective effects of the two loci on the disease penetrance: in particular, the occurrence and number of prostate cancer cases within a family were utilized to evaluate the interactions between the two loci under the additive and multiplicative Poisson regression models. The risk alleles A at rs4242382 (OR = 1.14, 95% CI 1.08-1.19, P2 = 13.89, P

Alkuperäiskieli	Englanti
Artikkeli	e89508
Sivut	e89508
Julkaisu	PLoS One
Vuosikerta	9
Numero	2
DOI - pysyväislinkit	https://doi.org/10.1371/journal.pone.0089508
Tila	Julkaistu - 2014
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

Jufo-taso 2

YK:n kestävän kehityksen tavoitteet

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Pääsy asiakirjaan

10.1371/journal.pone.0089508

Siteeraa tätä

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title = "Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis",

abstract = "Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228 cases in 75 families, to evaluate the respective effects of the two loci on the disease penetrance: in particular, the occurrence and number of prostate cancer cases within a family were utilized to evaluate the interactions between the two loci under the additive and multiplicative Poisson regression models. The risk alleles A at rs4242382 (OR = 1.14, 95% CI 1.08-1.19, P2 = 13.89, P",

author = "Chen, {Li Sheng} and Fann, {Jean Ching Yuan} and Chiu, {Sherry Yueh Hsia} and Yen, {Amy Ming Fang} and Tiina Wahlfors and Tammela, {Teuvo L.} and Chen, {Hsiu Hsi} and Anssi Auvinen and Johanna Schleutker",

year = "2014",

doi = "10.1371/journal.pone.0089508",

language = "English",

volume = "9",

pages = "e89508",

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TY - JOUR

T1 - Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis

AU - Chen, Li Sheng

AU - Fann, Jean Ching Yuan

AU - Chiu, Sherry Yueh Hsia

AU - Yen, Amy Ming Fang

AU - Wahlfors, Tiina

AU - Tammela, Teuvo L.

AU - Chen, Hsiu Hsi

AU - Auvinen, Anssi

AU - Schleutker, Johanna

PY - 2014

Y1 - 2014

N2 - Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228 cases in 75 families, to evaluate the respective effects of the two loci on the disease penetrance: in particular, the occurrence and number of prostate cancer cases within a family were utilized to evaluate the interactions between the two loci under the additive and multiplicative Poisson regression models. The risk alleles A at rs4242382 (OR = 1.14, 95% CI 1.08-1.19, P2 = 13.89, P

AB - Understanding the impact of multiple genetic variants and their interactions on the disease penetrance of familial multiple prostate cancer is very relevant to the overall understanding of carcinogenesis. We assessed the joint effect of two loci on rs4242382 at 8q24 and rs10486567 at 7p15.2 to this end. We analyzed the data from a Finnish family-based genetic study, which was composed of 947 men including 228 cases in 75 families, to evaluate the respective effects of the two loci on the disease penetrance: in particular, the occurrence and number of prostate cancer cases within a family were utilized to evaluate the interactions between the two loci under the additive and multiplicative Poisson regression models. The risk alleles A at rs4242382 (OR = 1.14, 95% CI 1.08-1.19, P2 = 13.89, P

U2 - 10.1371/journal.pone.0089508

DO - 10.1371/journal.pone.0089508

M3 - Article

AN - SCOPUS:84896099605

SN - 1932-6203

VL - 9

SP - e89508

JO - PLoS One

JF - PLoS One

IS - 2

M1 - e89508

ER -

Assessing interactions of two loci (rs4242382 and rs10486567) in familial prostate cancer: Statistical evaluation of epistasis

Abstrakti

Julkaisufoorumi-taso

YK:n kestävän kehityksen tavoitteet

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