Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Vanessa Schoissengeier; Lina Maqboul; Daniela Weber; Tilman Grune; Alexander Bürkle; Maria Moreno-Villaneuva; Claudio Franceschi; Miriam Capri; Jürgen Bernhard; Olivier Toussaint; Florence Debacq-Chainiaux; Birgit Weinberger; Efstathios S. Gonos; Ewa Sikora; Martijn Dollé; Eugène Jansen; P. Eline Slagboom; Antti Hervonen; Mikko Hurme; Nicolle Breusing; Jan Frank; Andrew C. Bulmer; Karl Heinz Wagner

doi:10.1016/j.isci.2024.110234

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

Vanessa Schoissengeier, Lina Maqboul, Daniela Weber, Tilman Grune, Alexander Bürkle, Maria Moreno-Villaneuva, Claudio Franceschi, Miriam Capri, Jürgen Bernhard, Olivier Toussaint, Florence Debacq-Chainiaux, Birgit Weinberger, Efstathios S. Gonos, Ewa Sikora, Martijn Dollé, Eugène Jansen, P. Eline Slagboom, Antti Hervonen, Mikko Hurme, Nicolle BreusingJan Frank, Andrew C. Bulmer, Karl Heinz Wagner

Lapset ja naiset, diagnostiset alat, psykiatria

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

2 Sitaatiot (Scopus)

23 Lataukset (Pure)

Abstrakti

Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

Alkuperäiskieli	Englanti
Artikkeli	110234
Julkaisu	Iscience
Vuosikerta	27
Numero	7
DOI - pysyväislinkit	https://doi.org/10.1016/j.isci.2024.110234
Tila	Julkaistu - 19 heinäk. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

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10.1016/j.isci.2024.110234Lisenssi: CC BY-NC-ND

1-s2.0-S2589004224014597-mainFinal published version, 2,65 MBLisenssi: CC BY-NC-ND

https://urn.fi/URN:NBN:fi:tuni-202407187673Lisenssi: CC BY-NC-ND

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Schoissengeier, V., Maqboul, L., Weber, D., Grune, T., Bürkle, A., Moreno-Villaneuva, M., Franceschi, C., Capri, M., Bernhard, J., Toussaint, O., Debacq-Chainiaux, F., Weinberger, B., Gonos, E. S., Sikora, E., Dollé, M., Jansen, E., Slagboom, P. E., Hervonen, A., Hurme, M., ... Wagner, K. H. (2024). Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort. Iscience, 27(7), Artikkeli 110234. https://doi.org/10.1016/j.isci.2024.110234

@article{377c0edb9fbe4b328102f97de0e94ca8,

title = "Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort",

abstract = "Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.",

keywords = "human metabolism, pathology, public health",

author = "Vanessa Schoissengeier and Lina Maqboul and Daniela Weber and Tilman Grune and Alexander B{\"u}rkle and Maria Moreno-Villaneuva and Claudio Franceschi and Miriam Capri and J{\"u}rgen Bernhard and Olivier Toussaint and Florence Debacq-Chainiaux and Birgit Weinberger and Gonos, {Efstathios S.} and Ewa Sikora and Martijn Doll{\'e} and Eug{\`e}ne Jansen and Slagboom, {P. Eline} and Antti Hervonen and Mikko Hurme and Nicolle Breusing and Jan Frank and Bulmer, {Andrew C.} and Wagner, {Karl Heinz}",

note = "Publisher Copyright: {\textcopyright} 2024",

year = "2024",

month = jul,

day = "19",

doi = "10.1016/j.isci.2024.110234",

language = "English",

volume = "27",

number = "7",

}

Schoissengeier, V, Maqboul, L, Weber, D, Grune, T, Bürkle, A, Moreno-Villaneuva, M, Franceschi, C, Capri, M, Bernhard, J, Toussaint, O, Debacq-Chainiaux, F, Weinberger, B, Gonos, ES, Sikora, E, Dollé, M, Jansen, E, Slagboom, PE, Hervonen, A, Hurme, M, Breusing, N, Frank, J, Bulmer, AC & Wagner, KH 2024, 'Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort', Iscience, Vuosikerta 27, Nro 7, 110234. https://doi.org/10.1016/j.isci.2024.110234

TY - JOUR

T1 - Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

AU - Schoissengeier, Vanessa

AU - Maqboul, Lina

AU - Weber, Daniela

AU - Grune, Tilman

AU - Bürkle, Alexander

AU - Moreno-Villaneuva, Maria

AU - Franceschi, Claudio

AU - Capri, Miriam

AU - Bernhard, Jürgen

AU - Toussaint, Olivier

AU - Debacq-Chainiaux, Florence

AU - Weinberger, Birgit

AU - Gonos, Efstathios S.

AU - Sikora, Ewa

AU - Dollé, Martijn

AU - Jansen, Eugène

AU - Slagboom, P. Eline

AU - Hervonen, Antti

AU - Hurme, Mikko

AU - Breusing, Nicolle

AU - Frank, Jan

AU - Bulmer, Andrew C.

AU - Wagner, Karl Heinz

PY - 2024/7/19

Y1 - 2024/7/19

N2 - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

AB - Recent studies have shown that elevated concentrations of unconjugated bilirubin (UCB) may be a protective host factor against the development of noncommunicable diseases (NCDs), whereas low levels of UCB are associated with the opposite effect. The results of this European study, in which 2,489 samples were tested for their UCB concentration using high-performance liquid chromatography (HPLC) and additional data from the MARK-AGE database were used for analysis, provide further evidence that elevated UCB concentrations are linked to a lower risk of developing NCDs and may act as a predictive marker of biological aging as individuals with elevated UCB concentrations showed favorable outcomes in metabolic health and oxidative-stress-related biomarkers. These findings underline the significance of studying individuals with moderate hyperbilirubinemia and investigate UCB routinely, also in the setting of aging, since this condition affects millions of people worldwide but has been underrepresented in clinical research and practice until now.

KW - human metabolism

KW - pathology

KW - public health

U2 - 10.1016/j.isci.2024.110234

DO - 10.1016/j.isci.2024.110234

M3 - Article

AN - SCOPUS:85196540049

SN - 2589-0042

VL - 27

JO - Iscience

JF - Iscience

IS - 7

M1 - 110234

ER -

Association between bilirubin and biomarkers of metabolic health and oxidative stress in the MARK-AGE cohort

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