Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

Marina O. Rontogianni; Dipender Gill; Emmanouil Bouras; Alexandros Georgios Asimakopoulos; Ioanna Tzoulaki; Ville Karhunen; Terho Lehtimäki; Olli Raitakari; Matthias Wielscher; Veikko Salomaa; Sirpa Jalkanen; Marko Salmi; Markku Timonen; James Yarmolinsky; Jing Chen; Martin D. Tobin; Abril G. Izquierdo; Karl Heinz Herzig; Anne E. Ioannides; Marjo Riitta Jarvelin; Abbas Dehghan; Konstantinos K. Tsilidis

doi:10.1016/j.isci.2024.110704

Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

Marina O. Rontogianni, Dipender Gill, Emmanouil Bouras, Alexandros Georgios Asimakopoulos, Ioanna Tzoulaki, Ville Karhunen, Terho Lehtimäki, Olli Raitakari, Matthias Wielscher, Veikko Salomaa, Sirpa Jalkanen, Marko Salmi, Markku Timonen, James Yarmolinsky, Jing Chen, Martin D. Tobin, Abril G. Izquierdo, Karl Heinz Herzig, Anne E. Ioannides, Marjo Riitta JarvelinAbbas Dehghan, Konstantinos K. Tsilidis

Tutkimustuotos: Artikkeli › Tieteellinen › vertaisarvioitu

5 Lataukset (Pure)

Abstrakti

We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

Alkuperäiskieli	Englanti
Artikkeli	110704
Sivumäärä	14
Julkaisu	Iscience
Vuosikerta	27
Numero	10
DOI - pysyväislinkit	https://doi.org/10.1016/j.isci.2024.110704
Tila	Julkaistu - 18 lokak. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

Julkaisufoorumi-taso

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10.1016/j.isci.2024.110704Lisenssi: CC BY

1-s2.0-S2589004224019291-mainFinal published version, 4,26 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-2024121111001Lisenssi: CC BY

Siteeraa tätä

Rontogianni, M. O., Gill, D., Bouras, E., Asimakopoulos, A. G., Tzoulaki, I., Karhunen, V., Lehtimäki, T., Raitakari, O., Wielscher, M., Salomaa, V., Jalkanen, S., Salmi, M., Timonen, M., Yarmolinsky, J., Chen, J., Tobin, M. D., Izquierdo, A. G., Herzig, K. H., Ioannides, A. E., ... Tsilidis, K. K. (2024). Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19. Iscience, 27(10), Artikkeli 110704. https://doi.org/10.1016/j.isci.2024.110704

@article{870f3db71a924551b068032758b22bdc,

title = "Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19",

abstract = "We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.",

keywords = "Association analysis, Disease, Health sciences, Respiratory medicine",

author = "Rontogianni, {Marina O.} and Dipender Gill and Emmanouil Bouras and Asimakopoulos, {Alexandros Georgios} and Ioanna Tzoulaki and Ville Karhunen and Terho Lehtim{\"a}ki and Olli Raitakari and Matthias Wielscher and Veikko Salomaa and Sirpa Jalkanen and Marko Salmi and Markku Timonen and James Yarmolinsky and Jing Chen and Tobin, {Martin D.} and Izquierdo, {Abril G.} and Herzig, {Karl Heinz} and Ioannides, {Anne E.} and Jarvelin, {Marjo Riitta} and Abbas Dehghan and Tsilidis, {Konstantinos K.}",

note = "Publisher Copyright: {\textcopyright} 2024 The Author(s)",

year = "2024",

month = oct,

day = "18",

doi = "10.1016/j.isci.2024.110704",

language = "English",

volume = "27",

number = "10",

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Rontogianni, MO, Gill, D, Bouras, E, Asimakopoulos, AG, Tzoulaki, I, Karhunen, V, Lehtimäki, T, Raitakari, O, Wielscher, M, Salomaa, V, Jalkanen, S, Salmi, M, Timonen, M, Yarmolinsky, J, Chen, J, Tobin, MD, Izquierdo, AG, Herzig, KH, Ioannides, AE, Jarvelin, MR, Dehghan, A & Tsilidis, KK 2024, 'Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19', Iscience, Vuosikerta 27, Nro 10, 110704. https://doi.org/10.1016/j.isci.2024.110704

TY - JOUR

T1 - Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

AU - Rontogianni, Marina O.

AU - Gill, Dipender

AU - Bouras, Emmanouil

AU - Asimakopoulos, Alexandros Georgios

AU - Tzoulaki, Ioanna

AU - Karhunen, Ville

AU - Lehtimäki, Terho

AU - Raitakari, Olli

AU - Wielscher, Matthias

AU - Salomaa, Veikko

AU - Jalkanen, Sirpa

AU - Salmi, Marko

AU - Timonen, Markku

AU - Yarmolinsky, James

AU - Chen, Jing

AU - Tobin, Martin D.

AU - Izquierdo, Abril G.

AU - Herzig, Karl Heinz

AU - Ioannides, Anne E.

AU - Jarvelin, Marjo Riitta

AU - Dehghan, Abbas

AU - Tsilidis, Konstantinos K.

PY - 2024/10/18

Y1 - 2024/10/18

N2 - We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

AB - We investigated the effects of 35 inflammatory cytokines on respiratory outcomes, including COVID-19, asthma (atopic and non-atopic), chronic obstructive pulmonary disease (COPD), and pulmonary function indices, using Mendelian randomization and colocalization analyses. The emerging associations were further explored using observational analyses in the UK Biobank. We found an inverse association between genetically predicted macrophage colony stimulating factor (MCSF), soluble intercellular adhesion molecule-1 (sICAM), and soluble vascular cell adhesion molecule-1 with risk of COVID-19 outcomes. sICAM was positively associated with atopic asthma risk, whereas tumor necrosis factor-alfa showed an inverse association. A positive association was shown between interleukin-18 and COPD risk (replicated in observational analysis), whereas an inverse association was shown for interleukin-1 receptor antagonist (IL-1ra). IL-1ra and monocyte chemotactic protein-3 were positively associated with lung function indices, whereas inverse associations were shown for MCSF and interleukin-18 (replicated in observational analysis). Our results point to these cytokines as potential pharmacological targets for respiratory traits.

KW - Association analysis

KW - Disease

KW - Health sciences

KW - Respiratory medicine

U2 - 10.1016/j.isci.2024.110704

DO - 10.1016/j.isci.2024.110704

M3 - Article

AN - SCOPUS:85207743948

SN - 2589-0042

VL - 27

JO - Iscience

JF - Iscience

IS - 10

M1 - 110704

ER -

Association of inflammatory cytokines with lung function, chronic lung diseases, and COVID-19

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