Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis

Nagendra K Monangi; Huan Xu; Yue-Mei Fan; Rasheeda Khanam; Waqasuddin Khan; Saikat Deb; Jesmin Pervin; Joan T Price; Lovejeet Kaur; INTERBIO-21st Study Consortium; Abdullah Al Mahmud; Le Quang Thanh; Angharad Care; Julio A Landero; Gerald F Combs; Elizabeth Belling; Joanne Chappell; Jing Chen; Fansheng Kong; Craig Lacher; Salahuddin Ahmed; Nabidul Haque Chowdhury; Sayedur Rahman; Furqan Kabir; Imran Nisar; Aneeta Hotwani; Usma Mehmood; Ambreen Nizar; Javairia Khalid; Usha Dhingra; Arup Dutta; Said Mohamed Ali; Fahad Aftab; Mohammed Hamad Juma; Monjur Rahman; Tahmeed Ahmed; M Munirul Islam; Bellington Vwalika; Patrick Musonda; Ulla Ashorn; Kenneth Maleta; Mikko Hallman; Laura Goodfellow; Juhi K Gupta; Ana Alfirevic; Susan K Murphy; Larry Rand; Kelli K Ryckman; Jeffrey C Murray; Rajiv Bahl; Per Ashorn

doi:10.1016/j.ajcnut.2023.10.011

Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis

Nagendra K Monangi, Huan Xu, Yue-Mei Fan, Rasheeda Khanam, Waqasuddin Khan, Saikat Deb, Jesmin Pervin, Joan T Price, Lovejeet Kaur, INTERBIO-21st Study Consortium, Abdullah Al Mahmud, Le Quang Thanh, Angharad Care, Julio A Landero, Gerald F Combs, Elizabeth Belling, Joanne Chappell, Jing Chen, Fansheng Kong, Craig LacherSalahuddin Ahmed, Nabidul Haque Chowdhury, Sayedur Rahman, Furqan Kabir, Imran Nisar, Aneeta Hotwani, Usma Mehmood, Ambreen Nizar, Javairia Khalid, Usha Dhingra, Arup Dutta, Said Mohamed Ali, Fahad Aftab, Mohammed Hamad Juma, Monjur Rahman, Tahmeed Ahmed, M Munirul Islam, Bellington Vwalika, Patrick Musonda, Ulla Ashorn, Kenneth Maleta, Mikko Hallman, Laura Goodfellow, Juhi K Gupta, Ana Alfirevic, Susan K Murphy, Larry Rand, Kelli K Ryckman, Jeffrey C Murray, Rajiv Bahl, Per Ashorn

LAST, Lastentaudit

Tutkimustuotos: Artikkeli › Scientific › vertaisarvioitu

16 Lataukset (Pure)

Abstrakti

BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).

OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.

METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.

RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.

CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.

Alkuperäiskieli	Englanti
Sivut	221-231
Sivumäärä	11
Julkaisu	American Journal of Clinical Nutrition
Vuosikerta	119
Numero	1
Varhainen verkossa julkaisun päivämäärä	27 lokak. 2023
DOI - pysyväislinkit	https://doi.org/10.1016/j.ajcnut.2023.10.011
Tila	Julkaistu - tammik. 2024
OKM-julkaisutyyppi	A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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10.1016/j.ajcnut.2023.10.011Lisenssi: CC BY

1-s2.0-S0002916523661854-mainFinal published version, 1,92 MBLisenssi: CC BY

https://urn.fi/URN:NBN:fi:tuni-202401151473Lisenssi: CC BY

Siteeraa tätä

Monangi, N. K., Xu, H., Fan, Y.-M., Khanam, R., Khan, W., Deb, S., Pervin, J., Price, J. T., Kaur, L., INTERBIO-21st Study Consortium, Al Mahmud, A., Thanh, L. Q., Care, A., Landero, J. A., Combs, G. F., Belling, E., Chappell, J., Chen, J., Kong, F., ... Ashorn, P. (2024). Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis. American Journal of Clinical Nutrition, 119(1), 221-231. https://doi.org/10.1016/j.ajcnut.2023.10.011

@article{d541407ec2804d9b9acf81c008a52be9,

title = "Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis",

abstract = "BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.",

keywords = "Pregnancy, Female, Humans, Infant, Newborn, Premature Birth, Copper, Gestational Age, Live Birth, Inflammation, Risk Factors",

author = "Monangi, {Nagendra K} and Huan Xu and Yue-Mei Fan and Rasheeda Khanam and Waqasuddin Khan and Saikat Deb and Jesmin Pervin and Price, {Joan T} and Lovejeet Kaur and {INTERBIO-21st Study Consortium} and {Al Mahmud}, Abdullah and Thanh, {Le Quang} and Angharad Care and Landero, {Julio A} and Combs, {Gerald F} and Elizabeth Belling and Joanne Chappell and Jing Chen and Fansheng Kong and Craig Lacher and Salahuddin Ahmed and Chowdhury, {Nabidul Haque} and Sayedur Rahman and Furqan Kabir and Imran Nisar and Aneeta Hotwani and Usma Mehmood and Ambreen Nizar and Javairia Khalid and Usha Dhingra and Arup Dutta and Ali, {Said Mohamed} and Fahad Aftab and Juma, {Mohammed Hamad} and Monjur Rahman and Tahmeed Ahmed and Islam, {M Munirul} and Bellington Vwalika and Patrick Musonda and Ulla Ashorn and Kenneth Maleta and Mikko Hallman and Laura Goodfellow and Gupta, {Juhi K} and Ana Alfirevic and Murphy, {Susan K} and Larry Rand and Ryckman, {Kelli K} and Murray, {Jeffrey C} and Rajiv Bahl and Per Ashorn",

note = "Copyright {\textcopyright} 2023. Published by Elsevier Inc.",

year = "2024",

month = jan,

doi = "10.1016/j.ajcnut.2023.10.011",

language = "English",

volume = "119",

pages = "221--231",

journal = "American Journal of Clinical Nutrition",

issn = "0002-9165",

publisher = "American Society for Nutrition",

number = "1",

}

Monangi, NK, Xu, H, Fan, Y-M, Khanam, R, Khan, W, Deb, S, Pervin, J, Price, JT, Kaur, L, INTERBIO-21st Study Consortium, Al Mahmud, A, Thanh, LQ, Care, A, Landero, JA, Combs, GF, Belling, E, Chappell, J, Chen, J, Kong, F, Lacher, C, Ahmed, S, Chowdhury, NH, Rahman, S, Kabir, F, Nisar, I, Hotwani, A, Mehmood, U, Nizar, A, Khalid, J, Dhingra, U, Dutta, A, Ali, SM, Aftab, F, Juma, MH, Rahman, M, Ahmed, T, Islam, MM, Vwalika, B, Musonda, P, Ashorn, U, Maleta, K, Hallman, M, Goodfellow, L, Gupta, JK, Alfirevic, A, Murphy, SK, Rand, L, Ryckman, KK, Murray, JC, Bahl, R & Ashorn, P 2024, 'Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis', American Journal of Clinical Nutrition, Vuosikerta 119, Nro 1, Sivut 221-231. https://doi.org/10.1016/j.ajcnut.2023.10.011

TY - JOUR

T1 - Association of maternal prenatal copper concentration with gestational duration and preterm birth

T2 - a multicountry meta-analysis

AU - Monangi, Nagendra K

AU - Xu, Huan

AU - Fan, Yue-Mei

AU - Khanam, Rasheeda

AU - Khan, Waqasuddin

AU - Deb, Saikat

AU - Pervin, Jesmin

AU - Price, Joan T

AU - Kaur, Lovejeet

AU - INTERBIO-21st Study Consortium

AU - Al Mahmud, Abdullah

AU - Thanh, Le Quang

AU - Care, Angharad

AU - Landero, Julio A

AU - Combs, Gerald F

AU - Belling, Elizabeth

AU - Chappell, Joanne

AU - Chen, Jing

AU - Kong, Fansheng

AU - Lacher, Craig

AU - Ahmed, Salahuddin

AU - Chowdhury, Nabidul Haque

AU - Rahman, Sayedur

AU - Kabir, Furqan

AU - Nisar, Imran

AU - Hotwani, Aneeta

AU - Mehmood, Usma

AU - Nizar, Ambreen

AU - Khalid, Javairia

AU - Dhingra, Usha

AU - Dutta, Arup

AU - Ali, Said Mohamed

AU - Aftab, Fahad

AU - Juma, Mohammed Hamad

AU - Rahman, Monjur

AU - Ahmed, Tahmeed

AU - Islam, M Munirul

AU - Vwalika, Bellington

AU - Musonda, Patrick

AU - Ashorn, Ulla

AU - Maleta, Kenneth

AU - Hallman, Mikko

AU - Goodfellow, Laura

AU - Gupta, Juhi K

AU - Alfirevic, Ana

AU - Murphy, Susan K

AU - Rand, Larry

AU - Ryckman, Kelli K

AU - Murray, Jeffrey C

AU - Bahl, Rajiv

AU - Ashorn, Per

PY - 2024/1

Y1 - 2024/1

N2 - BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.

AB - BACKGROUND: Copper (Cu), an essential trace mineral regulating multiple actions of inflammation and oxidative stress, has been implicated in risk for preterm birth (PTB).OBJECTIVES: This study aimed to determine the association of maternal Cu concentration during pregnancy with PTB risk and gestational duration in a large multicohort study including diverse populations.METHODS: Maternal plasma or serum samples of 10,449 singleton live births were obtained from 18 geographically diverse study cohorts. Maternal Cu concentrations were determined using inductively coupled plasma mass spectrometry. The associations of maternal Cu with PTB and gestational duration were analyzed using logistic and linear regressions for each cohort. The estimates were then combined using meta-analysis. Associations between maternal Cu and acute-phase reactants (APRs) and infection status were analyzed in 1239 samples from the Malawi cohort.RESULTS: The maternal prenatal Cu concentration in our study samples followed normal distribution with mean of 1.92 μg/mL and standard deviation of 0.43 μg/mL, and Cu concentrations increased with gestational age up to 20 wk. The random-effect meta-analysis across 18 cohorts revealed that 1 μg/mL increase in maternal Cu concentration was associated with higher risk of PTB with odds ratio of 1.30 (95% confidence interval [CI]: 1.08, 1.57) and shorter gestational duration of 1.64 d (95% CI: 0.56, 2.73). In the Malawi cohort, higher maternal Cu concentration, concentrations of multiple APRs, and infections (malaria and HIV) were correlated and associated with greater risk of PTB and shorter gestational duration.CONCLUSIONS: Our study supports robust negative association between maternal Cu and gestational duration and positive association with risk for PTB. Cu concentration was strongly correlated with APRs and infection status suggesting its potential role in inflammation, a pathway implicated in the mechanisms of PTB. Therefore, maternal Cu could be used as potential marker of integrated inflammatory pathways during pregnancy and risk for PTB.

KW - Pregnancy

KW - Female

KW - Humans

KW - Infant, Newborn

KW - Premature Birth

KW - Copper

KW - Gestational Age

KW - Live Birth

KW - Inflammation

KW - Risk Factors

U2 - 10.1016/j.ajcnut.2023.10.011

DO - 10.1016/j.ajcnut.2023.10.011

M3 - Article

C2 - 37890672

SN - 0002-9165

VL - 119

SP - 221

EP - 231

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

IS - 1

ER -

Association of maternal prenatal copper concentration with gestational duration and preterm birth: a multicountry meta-analysis

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