Associations of resting and peak fat oxidation with sex hormone profile and blood glucose control in middle-aged women

Jari E. Karppinen, Hanna Kaarina Juppi, Jukka Hintikka, Petri Wiklund, Eero A. Haapala, Matti Hyvärinen, Tuija H. Tammelin, Pauliina Aukee, Urho M. Kujala, Jari Laukkanen, Eija K. Laakkonen

    Tutkimustuotos: ArtikkeliTieteellinenvertaisarvioitu

    3 Sitaatiot (Scopus)
    7 Lataukset (Pure)

    Abstrakti

    Background and aims: Menopause may reduce fat oxidation. We investigated whether sex hormone profile explains resting fat oxidation (RFO) or peak fat oxidation (PFO) during incremental cycling in middle-aged women. Secondarily, we studied associations of RFO and PFO with glucose regulation. Method and results: We measured RFO and PFO of 42 women (age 52–58 years) with indirect calorimetry. Seven participants were pre- or perimenopausal, 26 were postmenopausal, and nine were postmenopausal hormone therapy users. Serum estradiol (E2), follicle-stimulating hormone, progesterone, and testosterone levels were quantified with immunoassays. Insulin sensitivity (Matsuda index) and glucose tolerance (area under the curve) were determined by glucose tolerance testing. Body composition was assessed with dual-energy X-ray absorptiometry; physical activity with self-report and accelerometry; and diet, with food diaries. Menopausal status or sex hormone levels were not associated with the fat oxidation outcomes. RFO determinants were fat mass (β = 0.44, P = 0.006) and preceding energy intake (β = −0.40, P = 0.019). Cardiorespiratory fitness (β = 0.59, P = 0.002), lean mass (β = 0.49, P = 0.002) and physical activity (self-reported β = 0.37, P = 0.020; accelerometer-measured β = 0.35, P = 0.024) explained PFO. RFO and PFO were not related to insulin sensitivity. Higher RFO was associated with poorer glucose tolerance (β = 0.52, P = 0.002). Conclusion: Among studied middle-aged women, sex hormone profile did not explain RFO or PFO, and higher fat oxidation capacity did not indicate better glucose control.

    AlkuperäiskieliEnglanti
    Sivut2157-2167
    Sivumäärä11
    JulkaisuNUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
    Vuosikerta32
    Numero9
    DOI - pysyväislinkit
    TilaJulkaistu - syysk. 2022
    OKM-julkaisutyyppiA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

    Julkaisufoorumi-taso

    • Jufo-taso 1

    !!ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Endocrinology, Diabetes and Metabolism
    • Nutrition and Dietetics
    • Cardiology and Cardiovascular Medicine

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