TY - JOUR
T1 - Central obesity in school-aged children increases the likelihood of developing paediatric autoimmune diseases
AU - Räisänen, Laura
AU - Lommi, Sohvi
AU - Engberg, Elina
AU - Kolho, Kaija Leena
AU - Viljakainen, Heli
N1 - Funding Information:
The study was supported by Folkhälsan's research fund and the Päivikki Sakari Sohlberg Foundation. In addition, Laura Räisänen received Tampere University Hospital's research grant. Kaija‐Leena Kolho received Helsinki University Grant and a Grant from Pediatric Research Foundation.
Funding Information:
Folkhälsan Research Fund; Päivikki and Sakari Sohlberg Foundation; Tampere University Hospital Research Fund Funding information
PY - 2022/3
Y1 - 2022/3
N2 - Background: The incidences of both paediatric obesity and autoimmune diseases have been increasing, but their relationship with one another is unclear. Objective: To determine whether obesity or particular dietary patterns in school-aged children are potential risk factors for autoimmune diseases during adolescence. Methods: This matched case–control study included 525 children, followed up from a median age of 11.3 to 16.7 years. Of them, 105 children received primary autoimmune diagnoses (diabetes, thyroiditis, arthritis, or inflammatory bowel diseases) after baseline and generated the case group. Four children with matching age, sex, and residential area generated the control group of 420 children. At baseline, age- and sex-specific body mass index categories were acquired and waist-to-height ratio (WHTR) was calculated. Central obesity was present when WHTR ≥0.5. Dietary patterns were analysed using a food frequency questionnaire (FFQ). Results: School-aged children with central obesity were 2.11 (OR, 95% CI 1.11–3.98) times more likely to develop autoimmune diseases before age of 19 years than those without central obesity. Being overweight was not related to the onset of these diseases (OR 1.60, 95% CI 0.89–2.87, nor were dietary patterns. Conclusion: Central obesity in school-aged children was related to the development of autoimmune diseases, while being overweight and dietary patterns were not.
AB - Background: The incidences of both paediatric obesity and autoimmune diseases have been increasing, but their relationship with one another is unclear. Objective: To determine whether obesity or particular dietary patterns in school-aged children are potential risk factors for autoimmune diseases during adolescence. Methods: This matched case–control study included 525 children, followed up from a median age of 11.3 to 16.7 years. Of them, 105 children received primary autoimmune diagnoses (diabetes, thyroiditis, arthritis, or inflammatory bowel diseases) after baseline and generated the case group. Four children with matching age, sex, and residential area generated the control group of 420 children. At baseline, age- and sex-specific body mass index categories were acquired and waist-to-height ratio (WHTR) was calculated. Central obesity was present when WHTR ≥0.5. Dietary patterns were analysed using a food frequency questionnaire (FFQ). Results: School-aged children with central obesity were 2.11 (OR, 95% CI 1.11–3.98) times more likely to develop autoimmune diseases before age of 19 years than those without central obesity. Being overweight was not related to the onset of these diseases (OR 1.60, 95% CI 0.89–2.87, nor were dietary patterns. Conclusion: Central obesity in school-aged children was related to the development of autoimmune diseases, while being overweight and dietary patterns were not.
KW - autoimmune thyroiditis (AIT)
KW - dietary patterns
KW - eating habits
KW - inflammatory bowel diseases (IBD)
KW - juvenile idiopathic arthritis (JIA)
KW - type 1 diabetes (DM)
U2 - 10.1111/ijpo.12857
DO - 10.1111/ijpo.12857
M3 - Article
AN - SCOPUS:85116187663
VL - 17
IS - 3
M1 - e12857
ER -